Understanding how blood flow affects clot formation and stroke risk in carotid webs
Determining the specific hemodynamics related to clot formation and subsequent stroke in subjects with carotid webs
This study is looking at how blood flows in the carotid artery of people with carotid webs, which can lead to strokes, to help understand what causes clots to form and improve treatment for those affected.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11120019 on NIH RePORTER |
What this research studies
This research investigates the hemodynamics, or blood flow dynamics, related to clot formation in patients with carotid webs, which are structures in the carotid artery linked to strokes in younger individuals. By analyzing imaging data from patients with and without clots, the study aims to quantify specific blood flow parameters that contribute to thromboembolism. The researchers will utilize advanced computational fluid dynamics simulations to better understand how these parameters influence clot formation. This knowledge could lead to improved management strategies for patients with carotid webs.
Who could benefit from this research
Good fit: Ideal candidates for this research are younger patients who have been diagnosed with carotid webs and have experienced cryptogenic strokes.
Not a fit: Patients who do not have carotid webs or those who have other underlying causes of stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide critical insights that lead to better prevention and treatment strategies for strokes associated with carotid webs.
How similar studies have performed: Previous research has shown promising results in understanding the hemodynamics of clot formation, but this study aims to provide more detailed insights using a larger and more robust dataset.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Oshinski, John N — Emory University
- Study coordinator: Oshinski, John N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.