NIH-funded research R21 grant

Understanding how blood flow affects clot formation and stroke risk in carotid webs

Official title: Determining the specific hemodynamics related to clot formation and subsequent stroke in subjects with carotid webs

Funded at Emory University · NIH-11120019 · Data updated 2026-11-12

This study is looking at how blood flows in the carotid artery of people with carotid webs, which can lead to strokes, to help understand what causes clots to form and improve treatment for those affected.

More Stroke research and trials

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionEmory University
NIH-funded
Lab location1 site (Atlanta, United States)
Project startApril 1, 2025
Project endMarch 31, 2027
Funding year2025
Award (this year)$217,472
NIH project number1R21NS142808-01
Project IDNIH-11120019 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are younger patients who have been diagnosed with carotid webs and have experienced cryptogenic strokes.

Less likely to help

Patients who do not have carotid webs or those who have other underlying causes of stroke may not benefit from this research.

What this research studies

This research investigates the hemodynamics, or blood flow dynamics, related to clot formation in patients with carotid webs, which are structures in the carotid artery linked to strokes in younger individuals. By analyzing imaging data from patients with and without clots, the study aims to quantify specific blood flow parameters that contribute to thromboembolism. The researchers will utilize advanced computational fluid dynamics simulations to better understand how these parameters influence clot formation. This knowledge could lead to improved management strategies for patients with carotid webs.

Why it matters

Potential benefit: If successful, this research could provide critical insights that lead to better prevention and treatment strategies for strokes associated with carotid webs.

How similar studies have gone: Previous research has shown promising results in understanding the hemodynamics of clot formation, but this study aims to provide more detailed insights using a larger and more robust dataset.

Where this research is happening

  • Emory University
    Atlanta, United States
    Active

Researchers

  • Principal investigator: Oshinski, John N — Emory University
  • Study coordinator: Oshinski, John N

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.