Sponsor or institution
Clinical trials and research at University of Pittsburgh at Pittsburgh
As of November 12, 2026, Find a Trial lists 2,429 NIH-funded research projects at this institution, with $1.6 billion in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 2429NIH research projects
NIH-funded research (newest 40 of 2429)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Elastomeric membranes for safer pelvic organ prolapse repair
A new 3D-printed elastomeric membrane made from polycarbonate urethane is being tested to replace stiff polypropylene meshes for pelvic organ prolapse in women, aiming to reduce complications.
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Role of hyaluronan in egg development and ovarian reserve
This grant studies how the hyaluronan matrix in the ovary affects the aging of the female reproductive system and the pool of eggs available.
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Regulatory switches that control imprinting in early human development
This grant studies how certain genes stay “one-copy” active in early development and what goes wrong in assisted reproduction, with a focus on imprinting disorders.
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Identifying molecular signs of imprinting errors linked to fertility treatments
This grant studies how assisted reproductive technologies may cause imprinting errors in embryos and how these errors relate to certain birth conditions, with implications for families using infertility treatments.
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Bioadhesive vaginal film for 7-day protection against HIV, HSV, and pregnancy
A vaginal film that slowly releases antibodies to prevent HIV, HSV, and unintended pregnancy for about a week from a single use.
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Spermatogonial stem cell transplantation and culture in patients
Researchers are testing a way to transplant or grow sperm-producing cells back in boys and men who stored tissue before cancer treatment, to help them have biological children in the future.
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Bioinspired repair for pubovisceral muscle injury after vaginal birth
A patient-friendly description of testing a bioinspired scaffold to repair PVME injuries that can help prevent pelvic organ prolapse.
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Understanding how maternal and infant sleep and daily rhythms influence early appetite and obesity risk
This project explores how infant sleep, circadian rhythms, and maternal-infant timing relate to early appetite patterns and the risk of obesity in the first year of life.
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Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
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New Vaccine Surveillance Network
A national effort to monitor common childhood viruses that cause stomach and breathing illnesses, helping doctors know which vaccines work best and when they are most effective.
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The National Spina Bifida Patient Registry at University of Pittsburgh
A national registry project at the University of Pittsburgh aims to collect and organize information about people with spina bifida to improve care.
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National Mesothelioma Biobank expands patient biospecimen and data sharing for research
A national biobank collects blood, tissue, and clinical data from mesothelioma patients to help researchers develop better diagnostics and treatments.
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Peer support and digital CBT to help adolescents and young adults with sickle cell pain
A multisite study will test a digital cognitive behavioral therapy program for Black adolescents and young adults with sickle cell pain, guided by peer supporters.
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CHD7's role in how cells move and shape developing kidneys
This project explores how CHD7 helps cells move and form organs during development, with potential implications for CHARGE syndrome.
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Modulating deep brain activity with focused ultrasound for cocaine use disorder
A study will test whether targeting a deep brain region with focused ultrasound can alter brain signals related to craving in people with cocaine use disorder.
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Targeted therapy for AML using DHODH inhibitors to boost differentiation and immune response
Aims to help adults with acute myeloid leukemia by using a special drug approach that makes cancer cells act more like normal blood cells and supports the immune system.
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Egfl6: a potential target to boost immune therapy in ovarian cancer
This grant tests whether targeting the protein Egfl6 can improve immune-based treatments for ovarian cancer by reducing immune-suppressing cells in the tumor environment.
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Targeting quiescent ovarian cancer cells to overcome chemotherapy resistance
A study focusing on why some ovarian cancer cells pause dividing and resist chemotherapy, with the goal of finding new treatment targets for relapsed disease.
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Gut bacteria and metabolites linked to breast density and cancer risk
A small, patient-friendly study will explore whether gut bacteria and their byproducts are connected to high breast density, which can raise cancer risk and make screening less accurate.
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East Palestine Train Derailment Health Research Program and Liver–Thyroid Health
A patient-facing program to study liver and thyroid health in people affected by the East Palestine train derailment and collect a biospecimen repository for future research.
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Maternal-Fetal Medicine Network clinical site at University of Pittsburgh
A hospital site is partnering with a national maternal-fetal medicine network to contribute patient data, samples, and clinical care to pregnancy research.
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Multi-Trait Genetic Analysis Using Large Biobank Data Linked to Health Records
Researchers will develop new genetic methods to better predict disease risk by combining large biobank data with electronic health records.
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Improving contraception decisions for women with substance use disorders after childbirth
A patient-centered decision tool called MyPath aims to help postpartum women with substance use disorders choose and keep effective contraception after giving birth.
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Helping communities use proven obesity-prevention ideas for kids
A study will test network-based approaches to help coalitions that serve underserved communities adopt proven obesity-prevention strategies for children.
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Blood biomarkers to monitor traumatic brain injury over time
Researchers are testing seven blood biomarkers to track how traumatic brain injury changes over time in patients.
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Integrated AI and Sensing Systems to Reduce Heart Failure Readmissions in Obese Adults
A new project from the University of Pittsburgh uses AI-powered wearables to monitor heart failure patients who are obese and help prevent readmissions.
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Imputing surface proteins to map cancer tumors in 3D tissue
Researchers will develop a way to predict which surface proteins appear in tumor tissues by combining spatial gene data with protein information to better understand cancer behavior.
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Ethically designed AI that guides personalized breast cancer treatment
A multi-center effort to build AI models using patient data to help tailor breast cancer treatment decisions for individual patients.
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Personalized immune-based care for septic kids with organ failure
A network study helps critically ill children with sepsis who have organ failure by tailoring treatments to their individual immune profiles.
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Decoding how developmental signals shape human tissues
A scientists-led project will study how spatial patterns of signaling molecules guide human stem cells to form tissues, with the goal of enabling better tissue repair and regenerative therapies.
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Understanding how the body works after weight loss to keep it off
This grant funds a coordinated effort to study why some people keep weight off after losing it, by tracking health data and biology in adults who undergo a weight loss program.
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Pitt-SDRC: A Center to Improve Care for AKI Survivors
A coordinated center aims to improve follow-up care and treatment for people who have survived moderate to severe acute kidney injury.
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Mechanisms and Targeting T Cell Regulation in Heart Transplant Monkeys
A patient-focused look at a study exploring how immune cells control heart transplant rejection and how to improve long-term graft survival.
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How neighborhood and money affect HIV care outcomes
A researcher at Johns Hopkins and later at University of Pittsburgh will study how people’s neighborhood and local wealth influence HIV care and outcomes using existing HIV patient data.
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COAST: Finding the best way to use SLT laser therapy for glaucoma
This NIH grant tests a gentler, ongoing laser treatment approach to help people with mild to moderate glaucoma or high-risk eye pressure stay in control longer without daily eye drops or surgery.
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Pediatric anesthesia and medication safety in dental care for kids and teens
A study to reduce the risk of adverse events from high-risk medications used in dental care for children and adolescents.
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Terminal cannabinoid CB1 receptor changes in schizophrenia and cannabis use
This grant studies how cannabis use and schizophrenia together affect a brain receptor (CB1) and what that could mean for memory and symptoms.
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Promoting and Visualizing Immune Regulation to Protect Transplants
A cutting-edge study looks for ways to prevent chronic rejection and help transplanted organs survive longer by boosting the body’s regulatory immune processes.
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Arterial stiffness, cognition, and equol: a trial to help aging adults
A large, multi-site study tests whether taking equol daily for two years can slow arterial stiffness, brain changes, and thinking difficulties in older adults without dementia.
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SenNet Data Center: sustaining and sharing cellular aging data and maps
A NIH-supported project keeps and shares the SenNet data resources and tools so researchers can map cellular senescence in human tissues.
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