Evaluating outcomes in cirrhosis and the effects of HIV and simvastatin
Prospective evaluation of outcomes in cirrhosis of different etiologies: impact of HIV infection and simvastatin therapy
This study is looking at how simvastatin might help people with liver disease from cirrhosis, especially those who also have HIV, by tracking their health and any changes in their strength and overall well-being over time.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11169467 on NIH RePORTER |
What this research studies
This research investigates the outcomes of patients with cirrhosis caused by different factors, particularly focusing on those who are also infected with HIV. The study aims to understand how simvastatin therapy might influence the progression of liver disease and related complications such as sarcopenia and frailty. By analyzing patient data and outcomes over time, the research seeks to identify predictors of disease progression and the impact of co-morbidities. Patients will be monitored for changes in their liver health and overall physical condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cirrhosis, especially those who are also living with HIV.
Not a fit: Patients without cirrhosis or those who do not have HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with cirrhosis, particularly those with HIV, enhancing their quality of life and survival rates.
How similar studies have performed: While there have been studies on cirrhosis and HIV separately, this specific approach combining these factors with simvastatin therapy is relatively novel.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Dasarathy, Srinivasan — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Dasarathy, Srinivasan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.