Evaluating outcomes in cirrhosis related to HIV and simvastatin treatment
Prospective evaluation of outcomes in cirrhosis of different etiologies: impact of HIV infection and simvastatin therapy
This study is looking at how simvastatin treatment affects people with cirrhosis who also have HIV, to see how it influences their liver health and related issues like muscle loss and weakness, so we can better understand how to help them feel better and improve their condition.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10909240 on NIH RePORTER |
What this research studies
This research investigates the outcomes of patients with cirrhosis, particularly focusing on those who are also infected with HIV and are receiving simvastatin therapy. The study aims to understand how these factors influence the progression of liver disease, including complications like sarcopenia and frailty. By analyzing patient data and outcomes over time, the research seeks to identify predictors of disease progression and the potential for reversing liver damage. Patients will be monitored for changes in their health status and the impact of treatment on their liver condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cirrhosis, especially those who are also HIV positive and may be receiving simvastatin.
Not a fit: Patients without cirrhosis or those not infected with HIV are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with cirrhosis, particularly those co-infected with HIV.
How similar studies have performed: While there has been research on cirrhosis and HIV, this specific approach focusing on simvastatin therapy and its effects on sarcopenia in cirrhosis is relatively novel.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Dasarathy, Srinivasan — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Dasarathy, Srinivasan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.