Understanding ANCA-Associated Vasculitis Relapse from Upper Airway Changes
Official title: Molecular and clinical predictors of relapse in ANCA-associated vasculitis
Funded at University of Pennsylvania · NIH-11141014 · Data updated 2026-11-12
This project aims to find early signs in the nose that can tell us when ANCA-associated vasculitis (AAV) might come back, helping doctors better manage the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 18, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $463,060 |
| NIH project number | 5R01AR084646-02 |
| Project ID | NIH-11141014 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with ANCA-associated vasculitis who are currently in remission but are at risk for future relapses would be most relevant to this research.
✕Less likely to help
Patients without ANCA-associated vasculitis or those not experiencing remission would likely not directly benefit from this specific research.
What this research studies
ANCA-associated vasculitis (AAV) is a serious condition that affects many organs, and it often starts with problems in the upper airway, like the nose. It's hard to know when AAV might flare up again, which means patients often take strong medications for a long time. This project looks closely at changes in nasal genes and bacteria, as well as patient-reported symptoms, to see if these can predict a relapse before it happens. By understanding these early warning signs, we hope to help doctors make better decisions about treatment, potentially reducing the need for long-term, strong medications.
Why it matters
Potential benefit: If successful, this work could lead to new ways to predict AAV relapses, allowing for more targeted treatment and potentially reducing the need for long-term, strong medications.
How similar studies have gone: This project builds on preliminary data showing that nasal changes can be detected before a systemic relapse, suggesting a promising foundation for this approach.
Where this research is happening
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University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Rhee, Rennie — University of Pennsylvania
- Study coordinator: Rhee, Rennie
Related research
Other NIH-funded projects on the same topics.
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Molecular and clinical clues to relapse in ANCA-related vasculitis
Researchers are studying nasal and airway signals, including bacteria and gene activity, to find predictors that a person with ANCA-associated vasculitis might relapse.
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Investigating predictors of relapse in ANCA-associated vasculitis
This study is looking at how certain genes and bacteria in the nose can help predict when people with ANCA-associated vasculitis might have a relapse, even if they aren't showing any symptoms, so doctors can better adjust their treatments and manage the condition.
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This study is looking at how a protein called alpha-1 antitrypsin influences immune cells in people with ANCA-associated vasculitis, a rare autoimmune disease, to help find better ways to treat and predict flare-ups for those affected.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.