Investigating predictors of relapse in ANCA-associated vasculitis
Molecular and clinical predictors of relapse in ANCA-associated vasculitis
This study is looking at how certain genes and bacteria in the nose can help predict when people with ANCA-associated vasculitis might have a relapse, even if they aren't showing any symptoms, so doctors can better adjust their treatments and manage the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10945401 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular and clinical factors that predict relapses in patients with ANCA-associated vasculitis (AAV), a disease that affects multiple organs and often involves the upper airway. By analyzing nasal gene expression and bacterial profiles, the study aims to identify changes that occur before a relapse, even in patients who show no symptoms. This could lead to the development of new biomarkers that help doctors make informed decisions about adjusting immunosuppressive therapies. The research also examines how sinonasal symptoms correlate with relapse risk, providing a comprehensive approach to managing AAV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ANCA-associated vasculitis who are currently in clinical remission.
Not a fit: Patients with other forms of vasculitis or those who are not diagnosed with ANCA-associated vasculitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prediction of relapses in AAV, allowing for timely adjustments in treatment and potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Rhee, Rennie — University of Pennsylvania
- Study coordinator: Rhee, Rennie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.