Investigating predictors of relapse in ANCA-associated vasculitis
Official title: Molecular and clinical predictors of relapse in ANCA-associated vasculitis
Funded at University of Pennsylvania · NIH-10945401 · Data updated 2026-11-12
This study is looking at how certain genes and bacteria in the nose can help predict when people with ANCA-associated vasculitis might have a relapse, even if they aren't showing any symptoms, so doctors can better adjust their treatments and manage the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 18, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $579,765 |
| NIH project number | 1R01AR084646-01 |
| Project ID | NIH-10945401 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with ANCA-associated vasculitis who are currently in clinical remission.
✕Less likely to help
Patients with other forms of vasculitis or those who are not diagnosed with ANCA-associated vasculitis may not benefit from this research.
What this research studies
This research focuses on understanding the molecular and clinical factors that predict relapses in patients with ANCA-associated vasculitis (AAV), a disease that affects multiple organs and often involves the upper airway. By analyzing nasal gene expression and bacterial profiles, the study aims to identify changes that occur before a relapse, even in patients who show no symptoms. This could lead to the development of new biomarkers that help doctors make informed decisions about adjusting immunosuppressive therapies. The research also examines how sinonasal symptoms correlate with relapse risk, providing a comprehensive approach to managing AAV.
Why it matters
Potential benefit: If successful, this research could lead to better prediction of relapses in AAV, allowing for timely adjustments in treatment and potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promise in identifying biomarkers for autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Rhee, Rennie — University of Pennsylvania
- Study coordinator: Rhee, Rennie
Related research
Other NIH-funded projects on the same topics.
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Molecular and clinical clues to relapse in ANCA-related vasculitis
Researchers are studying nasal and airway signals, including bacteria and gene activity, to find predictors that a person with ANCA-associated vasculitis might relapse.
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Understanding ANCA-Associated Vasculitis Relapse from Upper Airway Changes
This project aims to find early signs in the nose that can tell us when ANCA-associated vasculitis (AAV) might come back, helping doctors better manage the disease.
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Virtual Mind-Body Resiliency for SARDs (AAV and SLE)
A patient-facing program will test a virtual group-based mind-body approach to help people with ANCA-associated vasculitis and lupus cope with stress and improve well-being.
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Exploring the role of a protein in a type of blood vessel inflammation
This study is looking at how a protein called alpha-1 antitrypsin influences immune cells in people with ANCA-associated vasculitis, a rare autoimmune disease, to help find better ways to treat and predict flare-ups for those affected.
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FcgR-activated neutrophils shaping T cells in kidney and vessel inflammation
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.