FcgR-activated neutrophils shaping T cells in kidney and vessel inflammation
Official title: FcgR-activated neutrophil regulation of T cells in nephritis and vasculitis
Funded at University of Rochester · NIH-11523442 · Data updated 2026-11-12
This NIH grant explores how a specific neutrophil behavior may drive harmful T-cell activity in lupus-related kidney inflammation and vasculitis, with potential to inform new treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 10, 2025 |
| Project end | August 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $210,895 |
| NIH project number | 7R56HL179741-02 |
| Project ID | NIH-11523442 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with systemic lupus erythematosus, especially those with lupus nephritis or vasculitis, may benefit from future therapies arising from this work.
✕Less likely to help
Patients without lupus or kidney/vascular involvement may not directly benefit from this research.
What this research studies
The project looks at how neutrophils that act like antigen-presenting cells interact with T cells in lupus nephritis and vasculitis. By studying Fc gamma receptors on neutrophils and their ability to form highly immunogenic cells, the research aims to uncover mechanisms that worsen kidney and heart inflammation in SLE. Using humanized mice and disease models, the team will examine whether targeting these neutrophil-T cell interactions can reduce tissue damage. The findings could point to new therapeutic approaches for patients with lupus-related organ involvement.
Why it matters
Potential benefit: If successful, the work could lead to better treatments that prevent kidney and cardiovascular complications in SLE.
How similar studies have gone: Similar approaches have shown that neutrophil-T cell interactions can influence autoimmune pathology in lupus models, with promising translational potential.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Mayadas, Tanya N — University of Rochester
- Study coordinator: Mayadas, Tanya N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.