Malaria-related kidney injury and long-term kidney health in children
Official title: Malaria associated pathogenesis of chronic kidney disease (MAP-CKD)
Funded at Indiana University Indianapolis · NIH-11398915 · Data updated 2026-11-12
This grant looks at why severe malaria can cause kidney injury in children and how it may lead to lasting kidney problems, with research centered in Uganda.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | June 24, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $507,863 |
| NIH project number | 5R01AI165946-05 |
| Project ID | NIH-11398915 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are children in Uganda with severe malaria who develop AKI and consent to long-term follow-up.
✕Less likely to help
Children without severe malaria or without AKI may not directly benefit from this study.
What this research studies
In kids hospitalized with severe malaria, AKI is common and linked to higher risk of future CKD. The study will explore how persistent immune activation,血 vessel and red blood cell damage, and genetic factors like APOL1 influence maladaptive kidney repair after AKI. Researchers will use longitudinal follow-up in Uganda to track kidney function over time and examine biological pathways that might connect AKI to CKD. The goal is to identify mechanisms that could be targeted to prevent long-term kidney damage after severe malaria. Results could improve understanding of AKI-to-CKD progression in diverse pediatric populations, including Americans.
Why it matters
Potential benefit: If successful, the work could reveal targets to prevent CKD after AKI in children, potentially reducing long-term kidney complications.
How similar studies have gone: Prior findings support links between AKI and later CKD and suggest malaria-related pathways may drive this process, making the approach plausible but complex.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Conroy, Andrea L. — Indiana University Indianapolis
- Study coordinator: Conroy, Andrea L.
Related research
Other NIH-funded projects on the same topics.
-
Malaria-related kidney injury and its link to chronic kidney disease in children
This grant looks at why some children who have malaria develop kidney injury and later chronic kidney disease, focusing on how severe malaria affects the kidneys over time.
-
Malaria-linked long-term kidney damage in children
Following Ugandan children hospitalized with severe malaria to track kidney recovery and identify who may develop chronic kidney disease.
-
Personalized CKD-MBD care using systems biology and AI
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
-
Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
-
Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
-
Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.