Condition

Malaria clinical trials and research

• 19Clinical trials
• 406NIH research projects
• 13Countries

Newest Malaria clinical trials

All recruiting trials (19)

• Lotilaner safety and blood activity in healthy adults in Mali

  This Phase 1b study tests if a single dose of lotilaner is safe, tolerable, and shows mosquito-killing activity in healthy adults living in Mali.

  Recruiting Phase 1 Medicines for Malaria Venture · Bamako · NCT07758985

• See if the R21/Matrix-M malaria vaccine works in real-world settings for kids under 5

  This study tests how well the R21/Matrix-M vaccine protects children under 5 in Burkina Faso and Uganda when used in typical clinical care.

  Recruiting at 12 sites Clinton Health Access Initiative Inc. · Boromo, Boucle Mouhoun and 20 other locations · NCT07749911

• Do malaria vaccines lower the risk of invasive non-typhoidal Salmonella in young children?

  This study will see if the R21/Matrix-M malaria vaccine lowers the chance of invasive non-typhoidal Salmonella disease in children under 5 who come to health facilities with fever in the Kisantu Health Zone (DRC).

  Recruiting International Vaccine Institute · Kinshasa · NCT07416461

• Community spread of multiple infectious diseases in Cambodia from a One Health perspective

  This project will test how common and connected dengue, chikungunya, Zika, Japanese encephalitis, and West Nile infections are among people, animals, and the environment across Cambodia.

  Recruiting Institut Pasteur du Cambodge · Phnom Penh, Phnom Penh · NCT07358910

• Lower-dose and alternate-schedule RTS,S malaria vaccine for young children

  This project will test if smaller doses and different schedules of the RTS,S malaria vaccine are safe and help build immunity in healthy children aged 5 to 60 months who live where malaria is common.

  Recruiting at 2 sites Phase 2 GlaxoSmithKline · Kigali and 1 other locations · NCT07036159

• Optimizing malaria and HIV treatment for children in Busia and Kampala

  We will test whether dolutegravir affects growth and how it interacts with common malaria medicines in children with and without HIV, following them for two years in Busia and Kampala.

  Recruiting at 2 sites Phase 4 Yale University · Kampala and 1 other locations · NCT06967519

• Assessing the safety and infectivity of a malaria challenge agent in healthy adults

  This study is testing how the malaria parasite affects healthy adults and how their immune systems respond, to help develop better vaccines.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06607003

• Evaluating Artesunate Treatment in Infants with Severe Malaria

  This study is testing how safe and effective artesunate treatment is for infants under 2 years old with severe malaria by collecting blood samples during their first two days of treatment.

  Recruiting Amivas Inc. · Paris · NCT06555809

• Registry to assess pregnancy outcomes in Mali

  This study is collecting information about pregnancy and baby health in Mali to help test new treatments for preventing malaria during pregnancy.

  Recruiting National Institute of Allergy and Infectious Diseases (NIAID) · Kalifabougou, Koulikoro · NCT06468319

• L-citrulline supplementation during pregnancy to reduce adverse birth outcomes in Kenyan women at risk of malaria.

  This trial will test whether taking a twice-daily L-citrulline supplement during pregnancy helps Kenyan women at risk of malaria have healthier pregnancies and babies.

  Recruiting Liverpool School of Tropical Medicine · Kisumu · NCT05934318

• Comparing treatments for Plasmodium vivax malaria

  This study is testing whether a new malaria treatment called tafenoquine works better when combined with other antimalarial drugs for people with Plasmodium vivax malaria.

  Recruiting Phase 4 Shoklo Malaria Research Unit · Mae Sot, Changwat Tak · NCT05788094

• Focal mass drug administration to eliminate Vivax malaria

  This study is testing whether giving a special malaria treatment to people in certain villages can help reduce the spread of Vivax malaria in Peru.

  Recruiting Phase 3 University of California, San Francisco · Iquitos · NCT05690841

• Observing the safety of IV Artesunate treatment in pregnant women and their infants

  This study is trying to see if IV Artesunate treatment is safe for pregnant women with severe malaria and their babies.

  Recruiting Amivas Inc. · Piscataway, New Jersey · NCT05285735

• Evaluating the RTS,S malaria vaccine's safety and effectiveness

  This study is testing how safe and effective the RTS,S malaria vaccine is for young children in Ghana, Malawi, and Kenya.

  Recruiting at 4 sites Kintampo Health Research Centre, Ghana · Kintampo and 3 other locations · NCT05041556

• Collecting biological samples to study blood disorders

  This study is collecting samples from people with blood disorders and healthy volunteers to see how certain genetic factors affect these conditions and overall health.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03937817

• Screening healthy volunteers for malaria vaccine and drug studies

  This study is looking for healthy volunteers to see if they can join future research on malaria vaccines and treatments.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT02639299

• Evaluating malaria vaccine candidates for pregnant women

  This study is testing a new malaria vaccine for pregnant women to see if it can help protect them and their babies from malaria infections.

  Recruiting National Institutes of Health Clinical Center (CC) · Bamako · NCT02471378

• Understanding malaria infection and disease in pregnant women and young children in Mali

  This study is trying to understand how malaria affects pregnant women and young children in Mali to help improve health and develop better vaccines.

  Recruiting at 2 sites National Institutes of Health Clinical Center (CC) · Bamako and 1 other locations · NCT01168271

• Evaluation and treatment of patients with parasitic infections

  This study is testing how to better treat and monitor people with parasitic infections like malaria and intestinal worms, focusing on personalized care for anyone aged 1 and older.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00001645

NIH-funded research (newest 40 of 406)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Digital malaria surveillance in Ethiopia to improve outbreak detection

  A collaboration to add a malaria-specific digital module to an existing surveillance system in Africa to help detect and respond to outbreaks faster.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11624987

• Cross-sector partnership uses digital malaria surveillance in Ethiopia

  A US-based team will adapt and test a digital malaria surveillance module in SORMAS to help detect and respond to malaria outbreaks in Ethiopia.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11624985

• Malaria control project in Western Kenya to reduce illness and deaths

  A large, multi-year effort in western Kenya will help track malaria spread and test ways to prevent transmission so fewer people get sick or die.

  NIH research Tmliverpool School of Tropical Medicine · Liverpool, United Kingdom · NIH-11624227

• Optimizing tafenoquine dose to prevent relapse of vivax malaria in Asia

  A study tests the best tafenoquine dose to prevent P. vivax malaria relapse in people in East Asia and Oceania.

  NIH research University of Oxford · Oxford, United Kingdom · NIH-11619580

• Optimizing tafenoquine dose to prevent P. vivax malaria relapses in Asia

  A study to find the best single-dose tafenoquine amount to prevent relapse of P. vivax malaria in people in East Asia and Oceania.

  NIH research University of Oxford · Oxford, United Kingdom · NIH-11618631

• Severe malaria and brain risk in children

  This grant studies how severe malaria in young children can affect brain development and long-term thinking and behavior, with a focus on kids in Uganda.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11617675

• Post-flood malaria prevention: protecting kids and communities from malaria after heavy rains

  A study tests new malaria prevention strategies after severe flooding to see if giving preventive medicine to children and reducing mosquito habitats can cut malaria in rural Uganda.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11617038

• Post-flood malaria prevention: protecting kids and communities from severe flooding impacts

  A study in rural Uganda will test a malaria prevention plan after severe floods to see if giving a preventive medicine to children and using larval controls can lower malaria cases.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11617037

• Once Bitten: How to Build Broad Malaria Immunity

  Aims to develop a malaria vaccine strategy that induces broad, lasting protection against diverse parasite strains for people in malaria-affected areas and military personnel.

  NIH research Duke University · Durham, United States · NIH-11604499

• Aggressive fever-reducing therapy to protect the brains of children with CNS malaria

  A study planned for children with CNS malaria will test whether aggressive fever-reducing treatment can lower death and brain-related problems.

  NIH research University of Rochester · Rochester, United States · NIH-11604407

• Aggressive fever-reducing therapy to protect brains in children with CNS malaria

  A plan to test whether giving strong fever-reducing medications to children with central nervous system malaria can lower death and brain injury.

  NIH research University of Rochester · Rochester, United States · NIH-11604392

• Aggressive fever-fighting treatment to protect the brain in kids with CNS malaria

  A plan to test whether giving strong fever-reducing treatment alongside standard care can lower death and brain injury in children with CNS malaria.

  NIH research University of Rochester · Rochester, United States · NIH-11604356

• Aggressive fever-reducing treatment to protect brains in kids with CNS malaria

  A plan to test whether giving strong fever-reducing medicine alongside standard malaria treatment can lower deaths and brain injuries in children with CNS malaria.

  NIH research University of Rochester · Rochester, United States · NIH-11604355

• Aggressive fever-reducing treatment to protect the brain in children with CNS malaria

  A study tests whether giving strong fever-reducing medicines alongside standard care can lower death and brain-related problems in children with severe malaria affecting the brain.

  NIH research University of Rochester · Rochester, United States · NIH-11604354

• Aggressive fever-reducing therapy to protect the brain in children with CNS malaria

  This project plans a large, multi-country trial to test whether aggressive fever control helps reduce death and brain injury in African children with CNS malaria.

  NIH research University of Rochester · Rochester, United States · NIH-11604353

• Risk stratification of malaria in school-age children using mobile eye-based spectroscopy

  A low-cost, phone-based method uses pictures of the inner eyelid to identify which children in high-risk areas should get malaria tests.

  NIH research Purdue University · West Lafayette, United States · NIH-11599790

• Understanding how people and mosquitoes interact to boost malaria control in Uganda

  Aimed at better malaria prevention, this project looks at how human and mosquito behaviors affect how well bednets and other tools work in Uganda.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11591363

• Intermittent preventive treatment for malaria in schoolchildren to boost health and reduce transmission

  This grant tests giving full malaria drugs to school-aged children at regular intervals to improve kids’ health and help cut malaria spread in their communities.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11578584

• Understanding malaria in Southeast Asia: how the disease and its vectors change across the region

  This grant supports a large international effort to study how malaria spreads and evolves in Southeast Asia, including human and animal (zoonotic) infections, to help countries reach elimination.

  NIH research Mahidol University · Nakhon Pathom, Thailand · NIH-11573711

• Early-life malaria exposure and vaccine protection in Kenyan infants

  This project looks at how infections early in life affect how well malaria vaccines work in babies in Kenya.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11570691

• Impact of early-life malaria exposures on vaccine protection in Kenyan infants

  This grant tests how early malaria exposures affect how well malaria vaccines work in young children in Kenya.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11570690

• Structured switching network in malaria parasites and antigenic variation

  A malaria research grant aims to understand how Plasmodium falciparum changes its surface proteins to dodge the immune system, which could guide better vaccines and treatments for kids in Africa.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11565024

• Bioengineered human brain vessels to study cerebral malaria and explore new therapies

  Researchers are testing a new 3D model of human brain blood vessels to understand how cerebral malaria causes damage and to identify possible adjunctive treatments for children.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11563774

• How genetic diversity in malaria relates to vaccine candidates

  A malaria vaccine project at Yale looks at how differences in the parasite’s genes affect how well vaccine candidates might work in diverse populations.

  NIH research Yale University · New Haven, United States · NIH-11557209

• Identifying protective antibody responses to malaria in children

  Young children in Africa may develop antibodies that protect against malaria; this project maps which antibody features help prevent severe disease.

  NIH research Michigan State University · East Lansing, United States · NIH-11554571

• Relapsing malaria in Africa: understanding persistence of relapsing species in Africa

  A funded project in Africa and the U.S. seeks to understand why relapsing malaria species like P. vivax and P. ovale keep spreading, even as falciparum declines.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11550772

• Relapsing malaria in Africa: mechanisms for persistence amid falciparum decline

  Researchers are studying why relapsing malaria from parasites like P. ovale and P. vivax continues to persist in Africa even as P. falciparum declines, and how this could affect future control efforts.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11550771

• Artemisinin-resistant malaria in Ethiopia: who’s at risk and why it matters

  This grant looks at why some malaria parasites in Ethiopia are harder to treat with standard artemisinin-based medicines and what that means for patients.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11542575

• Impact of early malaria prevention on malaria risk at school entry

  This project looks at how early childhood malaria prevention strategies affect malaria risk by the time children start school in sub-Saharan Africa.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11538379

• Malaria vaccine and infection: how the body’s early and later immune responses relate to protection

  Researchers are studying how people’s immune systems respond to the malaria pre-erythrocytic stage, whether after vaccination or infection, to identify which responses are linked to protection.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11535221

• Malaria-related kidney injury and its link to chronic kidney disease in children

  This grant looks at why some children who have malaria develop kidney injury and later chronic kidney disease, focusing on how severe malaria affects the kidneys over time.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11524896

• Center studying hidden malaria infections in India

  A US NIH-funded center is helping India tackle malaria by studying hidden infections, mosquito transmission, and new biomarkers to support elimination efforts.

  NIH research London Sch/hygiene & Tropical Medicine · London, United Kingdom · NIH-11520863

• Center studying hidden malaria infections in India

  A national effort in India to understand why malaria persists by studying infections that are hard to detect and how to improve control strategies.

  NIH research London Sch/hygiene & Tropical Medicine · London, United Kingdom · NIH-11520862

• Improving newborn health with rapid malaria testing in pregnancy in Africa

  A funded project will test high-sensitivity malaria rapid tests to help manage malaria in pregnant people in Africa, aiming to reduce infant deaths and improve newborn health.

  NIH research Duke University · Durham, United States · NIH-11520770

• Improving neonatal health with rapid malaria testing in early pregnancy

  A study tests a high-sensitivity malaria test in pregnant people to help protect newborns in Africa.

  NIH research Duke University · Durham, United States · NIH-11519947

• Tracking malaria species and how they affect people in Burkina Faso

  This project looks at the different malaria parasites, how they spread, and how they cause illness across communities in Burkina Faso.

  NIH research Colorado State University · Fort Collins, United States · NIH-11518650

• How different malaria types affect people in Burkina Faso

  Teams will track which malaria species infect people and how they spread and cause illness across urban, rural, and mining communities in Burkina Faso.

  NIH research Colorado State University · Fort Collins, United States · NIH-11518535

• Understanding why malaria persists in Cameroon and how to stop it

  A study in Cameroon will track malaria transmission across different settings to identify which factors keep malaria a problem and how interventions could be made more effective for families and communities.

  NIH research University of South Florida · Tampa, United States · NIH-11518529

• Malaria surveillance and resistance research in Uganda to fight artemisinin resistance and transmission

  A U19 program in Uganda studies malaria, drug and insecticide resistance, and surveillance to help reduce illness and deaths from malaria in Africa.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11518108

• Understanding and overcoming barriers to malaria control in the Asia-Pacific

  A multi-site project tests new ways to track and reduce malaria in Cambodia, Papua New Guinea, and other Asia-Pacific areas to help communities move toward elimination.

  NIH research Walter and Eliza Hall Inst Medical Res · Parkville, AUSTRALIA · NIH-11516995

Related topics

Quick answers

How many Malaria clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (5 trials), Mali (4 trials), Uganda (2 trials), Kenya (2 trials), Peru (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 4: 2, Phase 3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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