Malaria-linked long-term kidney damage in children
Official title: Malaria associated pathogenesis of chronic kidney disease (MAP-CKD)
Funded at Indiana University Indianapolis · NIH-11088738 · Data updated 2026-11-12
Following Ugandan children hospitalized with severe malaria to track kidney recovery and identify who may develop chronic kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | June 24, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $386,610 |
| NIH project number | 5R01AI165946-04 |
| Project ID | NIH-11088738 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 90 days to 15 years who are hospitalized with severe malaria at participating Ugandan sites would be eligible, with community children enrolled as comparison participants.
✕Less likely to help
Adults, children without severe malaria, or people living outside the study areas in Uganda would not be eligible and would not directly benefit from this study.
What this research studies
If your child is hospitalized with severe malaria, researchers will enroll them and follow their kidney function over time and compare them to community children. The study will collect clinical data plus blood and urine samples to measure acute kidney injury, immune activation, and blood vessel (endothelial) function. Investigators plan to follow about 750 children hospitalized with severe malaria and roughly 189 community children across multiple sites in Uganda with repeated check-ups. The goal is to find why some children have persistent kidney injury and to identify signs that predict later chronic kidney disease.
Why it matters
Potential benefit: Could help doctors predict which children are at high risk for chronic kidney disease after severe malaria and point to ways to prevent or treat lasting kidney damage.
How similar studies have gone: Prior studies and the investigators' preliminary data have linked severe malaria-associated AKI to later kidney problems, but prospective multi-site follow-up to define mechanisms and predictors is relatively new.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Conroy, Andrea L. — Indiana University Indianapolis
- Study coordinator: Conroy, Andrea L.
Related research
Other NIH-funded projects on the same topics.
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Malaria-related kidney injury and its link to chronic kidney disease in children
This grant looks at why some children who have malaria develop kidney injury and later chronic kidney disease, focusing on how severe malaria affects the kidneys over time.
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Malaria-related kidney injury and long-term kidney health in children
This grant looks at why severe malaria can cause kidney injury in children and how it may lead to lasting kidney problems, with research centered in Uganda.
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Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
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Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.