Malaria-linked long-term kidney damage in children
Malaria associated pathogenesis of chronic kidney disease (MAP-CKD)
Following Ugandan children hospitalized with severe malaria to track kidney recovery and identify who may develop chronic kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11088738 on NIH RePORTER |
What this research studies
If your child is hospitalized with severe malaria, researchers will enroll them and follow their kidney function over time and compare them to community children. The study will collect clinical data plus blood and urine samples to measure acute kidney injury, immune activation, and blood vessel (endothelial) function. Investigators plan to follow about 750 children hospitalized with severe malaria and roughly 189 community children across multiple sites in Uganda with repeated check-ups. The goal is to find why some children have persistent kidney injury and to identify signs that predict later chronic kidney disease.
Who could benefit from this research
Good fit: Children aged 90 days to 15 years who are hospitalized with severe malaria at participating Ugandan sites would be eligible, with community children enrolled as comparison participants.
Not a fit: Adults, children without severe malaria, or people living outside the study areas in Uganda would not be eligible and would not directly benefit from this study.
Why it matters
Potential benefit: Could help doctors predict which children are at high risk for chronic kidney disease after severe malaria and point to ways to prevent or treat lasting kidney damage.
How similar studies have performed: Prior studies and the investigators' preliminary data have linked severe malaria-associated AKI to later kidney problems, but prospective multi-site follow-up to define mechanisms and predictors is relatively new.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Conroy, Andrea L. — Indiana University Indianapolis
- Study coordinator: Conroy, Andrea L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.