Understanding how different factors contribute to bone strength decline and hip fractures in older adults
Heterogeneous pathways to bone strength decline and hip fracture
This study is looking at how bone strength changes as we age and what factors might help predict the risk of hip fractures in older adults, so we can better understand and prevent these injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11074130 on NIH RePORTER |
What this research studies
This research investigates the various pathways that lead to a decline in bone strength and an increased risk of hip fractures in older men and women. It aims to identify specific skeletal trait patterns that can predict fracture risk, independent of traditional measures like areal bone mineral density (aBMD). By examining how different individuals experience changes in bone mineral content and bone area, the study seeks to improve fracture risk predictions. The research will involve analyzing data from cadaveric studies to understand the relationship between external bone size and strength decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those experiencing age-related bone strength decline.
Not a fit: Patients who are younger or have no risk factors for bone strength decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate predictions of fracture risk, allowing for better prevention strategies in older adults.
How similar studies have performed: Previous research has shown that understanding population heterogeneity can improve fracture risk predictions, suggesting this approach has potential for success.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Jepsen, Karl J — University of Michigan at Ann Arbor
- Study coordinator: Jepsen, Karl J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.