Developing a new treatment to improve muscle recovery after hip fractures in older adults
Official title: Preclinical Development of a Novel Therapeutic to Rejuvenate Aging Muscle Stem Cells and Enhance Muscle Strength and Function Post Hip Fracture
Funded at Ridgeline Therapeutics, LLC · NIH-11080486 · Data updated 2026-11-12
This study is testing a new pill called RT-002 to see if it can help older adults heal better and regain strength after a hip fracture, with the hope of making their recovery easier and improving their overall quality of life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ridgeline Therapeutics, LLC NIH-funded |
| Lab location | 1 site (Houston, UNITED STATES) |
| Project start | September 30, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $236,538 |
| NIH project number | 3U44AG074107-03S1 |
| Project ID | NIH-11080486 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 65 and older who have suffered a hip fracture.
✕Less likely to help
Patients under 65 years of age or those without a history of hip fractures may not benefit from this research.
What this research studies
This research focuses on RT-002, a novel oral therapeutic designed to help older adults recover more effectively from hip fractures. The study involves preclinical testing in various animal models to assess the safety and effectiveness of the treatment. By examining how RT-002 interacts with aging muscle stem cells, the researchers aim to enhance muscle strength and function post-injury. The ultimate goal is to improve the quality of life for patients who have experienced traumatic hip injuries.
Why it matters
Potential benefit: If successful, this research could significantly enhance recovery and quality of life for older adults after hip fractures.
How similar studies have gone: Previous research has shown promise in developing therapies for muscle recovery in older adults, indicating potential for success with this approach.
Where this research is happening
-
Ridgeline Therapeutics, LLC
Houston, United States Active
Researchers
- Principal investigator: Neelakantan, Harshini — Ridgeline Therapeutics, LLC
- Study coordinator: Neelakantan, Harshini
Related research
Other NIH-funded projects on the same topics.
-
Developing a new treatment to improve muscle strength in older adults after hip fractures
This study is testing a new treatment that helps older adults, especially those who have had hip fractures, regain muscle strength and improve their recovery after surgery by boosting their muscle repair cells.
-
Improving quality of life for older adults recovering from hip fractures
This study is all about helping older adults who have had hip fractures feel better and recover more easily in their neighborhoods by improving local services and support, especially for those in less advantaged areas.
-
MAC-STILA: Safer, gentler anesthesia for hip fracture in older adults
A multi-center trial tests a new anesthesia approach (MAC-STILA) to reduce delirium and other problems after hip-fracture surgery in older adults with dementia.
-
HIP ATTACK-2: Faster surgery for hip fracture patients with heart injury
A multicenter trial tests whether operating within 6 hours after hip fracture improves survival and recovery for patients who also have acute heart injury.
-
Hip fracture risk in people with chronic kidney disease
A study focused on why hip fractures happen and how to prevent them in people with chronic kidney disease.
-
Donepezil’s effect on aging muscles and resilience
A patient-friendly look at how a drug used for memory problems might help aging muscles stay stronger and more resilient.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.