Monitored sedation with local anesthetic injections for older adults with hip fracture
Monitored Anesthesia Care and Soft Tissue Infiltration with Local Anesthesia for Older Adults with Hip Fracture: A Multi-Center Feasibility Randomized Clinical Trial
This project compares monitored sedation plus local anesthesia injections to standard general anesthesia for older adults having hip fracture surgery to reduce postoperative delirium.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11226705 on NIH RePORTER |
What this research studies
If you are an older adult needing hip fracture surgery, doctors would randomize you to either monitored anesthesia care with surgeon-delivered local anesthetic injections (MAC-STILA) or standard general anesthesia. MAC-STILA uses carefully titrated IV sedation that preserves spontaneous breathing while the surgeon injects local anesthetic directly into the surgical site. The team will first build consensus on how to perform MAC-STILA across six hospitals, then enroll 140 patients and stratify them by baseline cognitive status. Researchers will track the incidence and severity of postoperative delirium and compare recovery between the two groups.
Who could benefit from this research
Good fit: Ideal candidates are older adults admitted for surgical repair of an acute hip fracture who are medically eligible for either monitored sedation with local infiltration or general anesthesia.
Not a fit: People without hip fractures, those who are not surgical candidates, or patients who require immediate general anesthesia or have contraindications to local anesthetic infiltration may not benefit or be eligible.
Why it matters
Potential benefit: If successful, this approach could lower the rate and severity of postoperative delirium and reduce anesthesia-related complications in older hip fracture patients.
How similar studies have performed: This specific MAC-STILA combination is relatively new and not widely tested, though some smaller studies of regional or lighter sedation techniques suggest possible reductions in delirium.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Konda, Sanjit — New York University School of Medicine
- Study coordinator: Konda, Sanjit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.