Monitored sedation with local anesthetic injections for older adults with hip fracture
Official title: Monitored Anesthesia Care and Soft Tissue Infiltration with Local Anesthesia for Older Adults with Hip Fracture: A Multi-Center Feasibility Randomized Clinical Trial
Funded at New York University School of Medicine · NIH-11226705 · Data updated 2026-11-12
This project compares monitored sedation plus local anesthesia injections to standard general anesthesia for older adults having hip fracture surgery to reduce postoperative delirium.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $705,726 |
| NIH project number | 1R01AG090860-01A1 |
| Project ID | NIH-11226705 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are older adults admitted for surgical repair of an acute hip fracture who are medically eligible for either monitored sedation with local infiltration or general anesthesia.
✕Less likely to help
People without hip fractures, those who are not surgical candidates, or patients who require immediate general anesthesia or have contraindications to local anesthetic infiltration may not benefit or be eligible.
What this research studies
If you are an older adult needing hip fracture surgery, doctors would randomize you to either monitored anesthesia care with surgeon-delivered local anesthetic injections (MAC-STILA) or standard general anesthesia. MAC-STILA uses carefully titrated IV sedation that preserves spontaneous breathing while the surgeon injects local anesthetic directly into the surgical site. The team will first build consensus on how to perform MAC-STILA across six hospitals, then enroll 140 patients and stratify them by baseline cognitive status. Researchers will track the incidence and severity of postoperative delirium and compare recovery between the two groups.
Why it matters
Potential benefit: If successful, this approach could lower the rate and severity of postoperative delirium and reduce anesthesia-related complications in older hip fracture patients.
How similar studies have gone: This specific MAC-STILA combination is relatively new and not widely tested, though some smaller studies of regional or lighter sedation techniques suggest possible reductions in delirium.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Konda, Sanjit — New York University School of Medicine
- Study coordinator: Konda, Sanjit
Related research
Other NIH-funded projects on the same topics.
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MAC-STILA: Safer, gentler anesthesia for hip fracture in older adults
A multi-center trial tests a new anesthesia approach (MAC-STILA) to reduce delirium and other problems after hip-fracture surgery in older adults with dementia.
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HIP ATTACK-2: Faster surgery for hip fracture patients with heart injury
A multicenter trial tests whether operating within 6 hours after hip fracture improves survival and recovery for patients who also have acute heart injury.
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Hip fracture risk in people with chronic kidney disease
A study focused on why hip fractures happen and how to prevent them in people with chronic kidney disease.
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How bones weaken in different ways that lead to hip fractures
This project looks at how differences in bone size, mineral content, and bone area relate to hip fracture risk in older men and women.
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Developing a new treatment to improve muscle recovery after hip fractures in older adults
This study is testing a new pill called RT-002 to see if it can help older adults heal better and regain strength after a hip fracture, with the hope of making their recovery easier and improving their overall quality of life.
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Understanding how different factors contribute to bone strength decline and hip fractures in older adults
This study is looking at how bone strength changes as we age and what factors might help predict the risk of hip fractures in older adults, so we can better understand and prevent these injuries.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.