Understanding the genetics of childhood acute lymphoblastic leukemia
Genomics of childhood acute lymphoblastic leukemia in the Childhood Cancer and Leukemia International Consortium
This study is looking at how certain genes might make kids aged 0-14 more likely to get acute lymphoblastic leukemia (ALL), and it hopes to find ways to better prevent and treat the disease by understanding how different backgrounds can affect this risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10890724 on NIH RePORTER |
What this research studies
This research investigates the genetic factors contributing to acute lymphoblastic leukemia (ALL) in children aged 0-14 years. By analyzing genetic data from diverse populations, the study aims to identify specific genetic variants that increase the risk of developing ALL. The approach includes genome-wide association studies (GWAS) to uncover common genetic markers associated with the disease. This research is particularly focused on understanding how ancestry influences the risk of ALL, which could lead to more tailored prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include children aged 0-14 years, particularly those from diverse ethnic backgrounds or with a family history of leukemia.
Not a fit: Patients who are older than 14 years or do not have a genetic predisposition to ALL may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted therapies for children at higher genetic risk for ALL.
How similar studies have performed: Previous research has successfully identified genetic risk factors for childhood cancers, suggesting that this approach could yield valuable insights into ALL.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Spector, Logan G. — University of Minnesota
- Study coordinator: Spector, Logan G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.