Understanding the genetics of childhood acute lymphoblastic leukemia
Official title: Genomics of childhood acute lymphoblastic leukemia in the Childhood Cancer and Leukemia International Consortium
Funded at University of Minnesota · NIH-10890724 · Data updated 2026-11-12
This study is looking at how certain genes might make kids aged 0-14 more likely to get acute lymphoblastic leukemia (ALL), and it hopes to find ways to better prevent and treat the disease by understanding how different backgrounds can affect this risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | August 22, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $544,994 |
| NIH project number | 5R01CA266253-03 |
| Project ID | NIH-10890724 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children aged 0-14 years, particularly those from diverse ethnic backgrounds or with a family history of leukemia.
✕Less likely to help
Patients who are older than 14 years or do not have a genetic predisposition to ALL may not benefit from this research.
What this research studies
This research investigates the genetic factors contributing to acute lymphoblastic leukemia (ALL) in children aged 0-14 years. By analyzing genetic data from diverse populations, the study aims to identify specific genetic variants that increase the risk of developing ALL. The approach includes genome-wide association studies (GWAS) to uncover common genetic markers associated with the disease. This research is particularly focused on understanding how ancestry influences the risk of ALL, which could lead to more tailored prevention and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted therapies for children at higher genetic risk for ALL.
How similar studies have gone: Previous research has successfully identified genetic risk factors for childhood cancers, suggesting that this approach could yield valuable insights into ALL.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Spector, Logan G. — University of Minnesota
- Study coordinator: Spector, Logan G.
Related research
Other NIH-funded projects on the same topics.
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Genomics of childhood ALL across global populations
A wide-ranging study looks at how inherited genetics influence the risk of childhood acute lymphoblastic leukemia around the world.
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Genomics of childhood ALL across diverse populations
A large international study will look at why children everywhere get acute lymphoblastic leukemia and how genetics may influence risk.
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Genomics of childhood acute lymphoblastic leukemia across global populations
This grant studies how inherited genes influence the risk of childhood ALL around the world to understand why some groups are more affected.
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Childhood acute lymphoblastic leukemia genetics around the world
This project compares inherited genetic differences in children with and without acute lymphoblastic leukemia across many countries to learn who is at higher risk.
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Genetics of childhood acute lymphoblastic leukemia
This project looks at how inherited genes affect the risk of acute lymphoblastic leukemia in children from many countries and ancestry groups.
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How inherited genes affect childhood acute lymphoblastic leukemia worldwide
This project looks at inherited gene differences that relate to the risk of children developing acute lymphoblastic leukemia across many countries.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.