Diversity of PDE2A Signaling in Traumatic Brain Injury and Alzheimer’s Disease

Who could benefit from this research

What this research studies

If you or a loved one has had a traumatic brain injury, this research looks at how a specific brain enzyme (PDE2A) changes with injury and may contribute to later dementia. The scientists will study mitochondria, the cell’s energy factories, and how PDE2A influences important channels and DNA leakage that can trigger inflammation. By examining the signaling pathways in brain cells, they hope to uncover mechanisms that connect TBI to Alzheimer's disease and related dementias. The goal is to identify potential targets that could protect brain energy and reduce neurodegeneration after injury.

Why it matters

Where this research is happening

• Rutgers Biomedical and Health Sciences
  Newark, United States Active

Researchers

• Principal investigator: Xu, Ying — Rutgers Biomedical and Health Sciences
• Study coordinator: Xu, Ying

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.