Exploring how brain injuries may increase the risk of Alzheimer's disease.

Who could benefit from this research

What this research studies

This research investigates the connection between traumatic brain injury (TBI) and the development of Alzheimer's disease (AD). It focuses on understanding how abnormal activation of the inflammasome, a part of the immune response, may contribute to the risk of developing AD after experiencing a TBI. By studying the inflammatory processes involved, the research aims to uncover potential therapeutic strategies that could mitigate the effects of TBI on brain health. Patients with a history of TBI may find this research particularly relevant as it seeks to clarify the underlying mechanisms linking these conditions.

Why it matters

Where this research is happening

• University of Miami School of Medicine
  Coral Gables, United States Active

Researchers

• Principal investigator: Dietrich, W Dalton — University of Miami School of Medicine
• Study coordinator: Dietrich, W Dalton

Related research

Other NIH-funded projects on the same topics.

• Diversity of PDE2A Signaling in Traumatic Brain Injury and Alzheimer’s Disease

  This project explores how an enzyme called PDE2A affects brain cell energy and inflammation after brain injury, to understand its link to Alzheimer’s-related dementia.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11238201

• Developing a new platform for testing drugs for Alzheimer's disease and traumatic brain injury

  This study is working on a new tiny chip that mimics Alzheimer's disease and related conditions to help test new drugs, with the hope of finding better treatments for the millions of people affected by these diseases.

  NIH research Bmseed, LLC · Tempe, United States · NIH-10997391

• Understanding how brain injuries affect blood stem cells and Alzheimer's disease risk

  This study is looking at how a traumatic brain injury might increase the risk of developing Alzheimer's disease by exploring changes in important immune cells, and it's aimed at helping people who have had brain injuries find ways to protect their long-term health.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-10995373

• How age at traumatic brain injury affects the risk of Alzheimer's disease and related dementias

  This study is looking at how a past head injury might affect the chances of developing Alzheimer's and similar memory problems later in life, especially considering things like age and genetics, to help find better ways to prevent and treat these conditions.

  NIH research University of California Riverside · Riverside, United States · NIH-10933845

• How mild traumatic brain injury affects neurodegeneration in older adults

  This study is looking at how mild traumatic brain injuries, which many Veterans experience, might affect memory and brain health over time, especially in relation to conditions like Alzheimer's disease, to help understand how these injuries can lead to cognitive decline.

  NIH research VA Boston Health Care System · Boston, United States · NIH-10919799

• Detecting and tracking brain injury-related degeneration and distinguishing it from Alzheimer's disease

  This study is working on a new way to spot Chronic Traumatic Encephalopathy (CTE) in living people, especially those who have had repeated head injuries, like athletes and older adults, by using brain scans and other tests to tell it apart from Alzheimer's and other types of dementia.

  NIH research Adm Diagnostics, INC. · Northbrook, United States · NIH-10709652

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.