Understanding how brain injuries affect blood stem cells and Alzheimer's disease risk
Hematopoietic stem cell dysfunction in traumatic brain injury and Alzheimer's disease
['FUNDING_FELLOWSHIP'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10995373
This study is looking at how a traumatic brain injury might increase the risk of developing Alzheimer's disease by exploring changes in important immune cells, and it's aimed at helping people who have had brain injuries find ways to protect their long-term health.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10995373 on ClinicalTrials.gov |
What this research studies
This research investigates the connection between traumatic brain injury (TBI) and Alzheimer's disease (AD) by focusing on how TBI affects hematopoietic stem cells (HSCs), which are crucial for immune function. The study aims to uncover the mechanisms that link acute TBI to chronic neurodegeneration and increased AD risk. By examining changes in HSC function following TBI, the research seeks to identify potential therapeutic strategies to protect patients from the long-term effects of brain injuries. This interdisciplinary approach combines insights from neurology and immunology to address a significant gap in understanding these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have suffered a traumatic brain injury and are at risk for developing Alzheimer's disease.
Not a fit: Patients who have not experienced a traumatic brain injury or do not have a risk of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or mitigating Alzheimer's disease in individuals who have experienced traumatic brain injuries.
How similar studies have performed: While the relationship between TBI and AD is recognized, this specific investigation into HSC dysfunction is novel and has not been extensively tested in prior research.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CORELLA, SOFIA — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: CORELLA, SOFIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia