How age at traumatic brain injury affects the risk of Alzheimer's disease and related dementias
Modeling the role of age at traumatic brain injury in the development of Alzheimer's Disease and related dementias
This study is looking at how a past head injury might affect the chances of developing Alzheimer's and similar memory problems later in life, especially considering things like age and genetics, to help find better ways to prevent and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-10933845 on NIH RePORTER |
What this research studies
This research investigates the long-term effects of traumatic brain injury (TBI) on the development of Alzheimer's disease and related dementias. Using a closed head injury model in rodents, the study will explore how factors like age and genetic risk alleles influence the progression of cognitive decline and neurodegenerative changes. Advanced imaging techniques and fluid biomarkers will be utilized to assess disease advancement over the lifespan of the subjects. The goal is to better understand the relationship between TBI and Alzheimer's risk, which could inform future prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a traumatic brain injury, particularly those with genetic risk factors for Alzheimer's disease.
Not a fit: Patients who have not experienced a traumatic brain injury or do not have risk factors for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potentially new interventions for individuals at risk of Alzheimer's disease following a traumatic brain injury.
How similar studies have performed: Previous research has shown that traumatic brain injury is a significant risk factor for Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Obenaus, Andre — University of California Riverside
- Study coordinator: Obenaus, Andre
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.