How age at traumatic brain injury affects the risk of Alzheimer's disease and related dementias

Who could benefit from this research

What this research studies

This research investigates the long-term effects of traumatic brain injury (TBI) on the development of Alzheimer's disease and related dementias. Using a closed head injury model in rodents, the study will explore how factors like age and genetic risk alleles influence the progression of cognitive decline and neurodegenerative changes. Advanced imaging techniques and fluid biomarkers will be utilized to assess disease advancement over the lifespan of the subjects. The goal is to better understand the relationship between TBI and Alzheimer's risk, which could inform future prevention and treatment strategies.

Why it matters

Where this research is happening

• University of California Riverside
  Riverside, United States Active

Researchers

• Principal investigator: Obenaus, Andre — University of California Riverside
• Study coordinator: Obenaus, Andre

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.