Developing a new platform for testing drugs for Alzheimer's disease and traumatic brain injury

Who could benefit from this research

What this research studies

This research focuses on creating an innovative microfluidic chip-based platform that models Alzheimer's disease and related dementias for preclinical drug testing. By integrating this platform with existing models for traumatic brain injury, the research aims to provide a more accurate representation of these conditions, which could lead to better drug development. Patients may benefit from this research as it seeks to address the lack of effective treatments for Alzheimer's disease, which currently affects millions. The approach involves advanced 3D cell culture techniques to simulate the disease environment more realistically.

Why it matters

Where this research is happening

• Bmseed, LLC
  Tempe, United States Active

Researchers

• Principal investigator: Graudejus, Oliver — Bmseed, LLC
• Study coordinator: Graudejus, Oliver

Related research

Other NIH-funded projects on the same topics.

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• How age at traumatic brain injury affects the risk of Alzheimer's disease and related dementias

  This study is looking at how a past head injury might affect the chances of developing Alzheimer's and similar memory problems later in life, especially considering things like age and genetics, to help find better ways to prevent and treat these conditions.

  NIH research University of California Riverside · Riverside, United States · NIH-10933845

• How mild traumatic brain injury affects neurodegeneration in older adults

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• Detecting and tracking brain injury-related degeneration and distinguishing it from Alzheimer's disease

  This study is working on a new way to spot Chronic Traumatic Encephalopathy (CTE) in living people, especially those who have had repeated head injuries, like athletes and older adults, by using brain scans and other tests to tell it apart from Alzheimer's and other types of dementia.

  NIH research Adm Diagnostics, INC. · Northbrook, United States · NIH-10709652

• Exploring how brain injuries may increase the risk of Alzheimer's disease.

  This study is looking at how a head injury might increase the chances of developing Alzheimer's disease by exploring the role of inflammation in the brain, and it's especially important for anyone who has had a traumatic brain injury.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-10700483

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.