Condition

Temporomandibular Disorder clinical trials and research

• 16Clinical trials
• 9NIH research projects
• 8Countries

Newest Temporomandibular Disorder clinical trials

All recruiting trials (16)

• Botulinum toxin for jaw myofascial pain in adults

  This study tests whether injecting botulinum toxin into jaw muscles helps reduce pain and improve mouth opening in adults with stubborn temporomandibular myofascial pain.

  Recruiting Phase 2 Riphah International University · Islamabad · NCT07847541

• What predicts how bad TMD is, involving jaw, neck, and posture

  We will test if jaw dysfunction, neck position sense, and head/neck posture relate to how severe temporomandibular disorders are in adults.

  Recruiting Ankara Yildirim Beyazıt University · Ankara · NCT07666360

• Nerivio in adults and adolescents with chronic TMD headache

  This study tests a Nerivio device to help people 12 and older with chronic temporomandibular disorder and headaches see if the treatment reduces pain.

  Recruiting at 4 sites Theranica · Newark, Delaware and 3 other locations · NCT07639944

• Daily ear vagus‑nerve stimulation to reduce TMD jaw and facial pain

  This will test whether daily, at‑home gentle electrical stimulation of the ear's vagus nerve can reduce chronic jaw and facial pain in adults with temporomandibular disorder (TMD).

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07517172

• Heat therapy for jaw pain in chronic TMD

  This study tests whether applying local heat to the jaw can reduce pain and jaw fatigue in adults with chronic temporomandibular disorder during a clenching task.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07153107

• Using Botulinumtoxin A to treat pain in jaw disorders

  This study is testing if Botulinumtoxin A injections can help reduce pain and improve life for people with jaw disorders caused by muscle issues.

  Recruiting Phase 3 Region Stockholm · Stockholm · NCT06941636

• Investigating the link between levonorgestrel intrauterine system and temporomandibular disorders

  This study is trying to see if using a specific birth control device called the levonorgestrel intrauterine system is linked to jaw joint problems in women.

  Recruiting Marmara University · Istanbul, Maltepe · NCT06500390

• Using osteopathic manual therapy for treating temporomandibular disorders in fibromyalgia patients

  This study is testing if a special hands-on treatment can help people with fibromyalgia and jaw pain feel better.

  Recruiting Universitat de Lleida · Cornellà de Llobregat, Barcelona · NCT06365151

• Behavioral intervention for chronic jaw pain via telehealth

  This study is testing a new online program to help people with chronic jaw pain feel better by teaching them how to manage their pain and comparing it to a regular education program.

  Recruiting University of Kentucky · Lexington, Kentucky · NCT06357702

• Mandibular nerve electrical stimulation for TMJ pain and jaw function

  This trial will try percutaneous electrical stimulation of the mandibular nerve to reduce pain and improve jaw movement in people with myofascial temporomandibular disorder.

  Recruiting OrigenKinesis fisioterapia · Alcorcón, Madrid · NCT06265636

• Exploring virtual reality for managing chronic pain in TMD patients

  This study is testing if using virtual reality can help people with chronic pain from temporomandibular disorder feel better compared to a fake VR experience.

  Recruiting at 2 sites University of Maryland, Baltimore · Baltimore, Maryland and 1 other locations · NCT06214923

• Evaluating a questionnaire for patients with jaw disorders

  This study is testing a new questionnaire to see if it accurately measures how temporomandibular disorders affect people's mental health and quality of life.

  Recruiting at 2 sites Hacettepe University · Karabük, Karabük Province and 1 other locations · NCT06186830

• Comparing aerobic exercise to localized pain relief exercises for jaw and neck pain

  This study tests whether aerobic exercise or targeted pain relief exercises can help people aged 18-60 with chronic neck pain and jaw issues feel better and move more easily.

  Recruiting Hochschule Osnabruck · Osnabrück, Lower Saxony · NCT05232604

• Comparing intraoral and extraoral manual therapy for jaw pain

  This study is testing whether therapy done inside the mouth works better than therapy done outside the mouth for people with jaw pain from temporomandibular disorders.

  Recruiting University of Alcala · Alcalá de Henares, Madrid · NCT05167656

• Tele-rehabilitation for patients with jaw joint disorders

  This study is testing if remote therapy can help people with jaw joint disorders feel less pain and move their jaws better.

  Recruiting University of Nove de Julho · São Paulo · NCT05006963

• New treatment approach for temporomandibular disorders

  This study is testing a new way to treat jaw pain by adjusting pressure in the jaw joint to see if it helps people with temporomandibular disorders feel better.

  Recruiting Sun Yat-sen University · Guangzhou, Guangdong · NCT00932594

NIH-funded research (9)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Photobiomodulation for jaw pain from TMD

  A clinician-scientist at the University of Florida is testing a light-based therapy to help adults with temporomandibular disorder pain feel better and jaw function improve.

  NIH research University of Florida · Gainesville, United States · NIH-11635590

• Targeted light therapy for jaw pain (TMD)

  This project uses targeted light therapy to try to reduce jaw pain in adults with temporomandibular disorder.

  NIH research University of Florida · Gainesville, United States · NIH-11382371

• Female-specific trigeminal dynorphin role in TMD and migraine overlap

  This grant studies why women with jaw pain (TMD) often have migraines and looks for female-focused targets to treat both conditions.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11380671

• Photobiomodulation for jaw pain from TMD

  A study tests a light-based therapy to help adults with temporomandibular disorder reduce jaw pain without drugs.

  NIH research University of Florida · Gainesville, United States · NIH-11361586

• Light Therapy for Jaw Pain

  This project is exploring if a special type of light therapy, called photobiomodulation, can help adults who experience chronic pain from temporomandibular disorder (TMD).

  NIH research University of Florida · Gainesville, United States · NIH-11144545

• Understanding jaw pain and migraine in women

  This project looks for new ways to treat jaw pain (TMD) and migraine headaches, especially in women.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11143871

• Investigating the role of a specific protein in pain related to jaw disorders and migraines in women

  This study is looking at how jaw pain from temporomandibular disorders (TMD) might be linked to migraine headaches in women, and it hopes to find new ways to help relieve that pain by exploring a specific protein involved in both conditions.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-10890894

• Using light therapy to relieve pain from jaw disorders

  This study is looking at how a gentle light therapy called Photobiomodulation can help relieve pain for people with jaw pain from Temporomandibular Disorders (TMD), and we're inviting community members to see if they qualify to participate!

  NIH research University of Florida · Gainesville, United States · NIH-10889280

• Targeting LPA signaling to treat temporomandibular disorder pain

  This study is looking at how a substance called lysophosphatidic acid (LPA) might be linked to the pain people feel from jaw problems, and it aims to find new ways to help relieve that pain more effectively.

  NIH research Duke University · Durham, United States · NIH-10853981

Related topics

Quick answers

How many Temporomandibular Disorder clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (5 trials), Turkey (Türkiye) (3 trials), Spain (3 trials), Pakistan (1 trial), Sweden (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →