Targeting LPA signaling to treat temporomandibular disorder pain
Identification and validation of LPA/LPAR signaling as a target for the treatment of temporomandibular disorder pain
This study is looking at how a substance called lysophosphatidic acid (LPA) might be linked to the pain people feel from jaw problems, and it aims to find new ways to help relieve that pain more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10853981 on NIH RePORTER |
What this research studies
This research investigates the role of lysophosphatidic acid (LPA) and its receptors in the pain associated with temporomandibular disorders (TMD). The team aims to validate LPA/LPAR signaling as a potential target for new pain treatments by studying its effects in both animal models and human tissues. By understanding how LPA contributes to pain in TMD, the researchers hope to develop more effective, mechanism-based therapies that could reduce pain and side effects compared to current treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with temporomandibular disorders experiencing chronic pain.
Not a fit: Patients without temporomandibular disorders or those whose pain is not related to LPA signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from temporomandibular disorder pain.
How similar studies have performed: Previous research has shown promise in targeting LPA signaling for pain management, but this specific application to TMD is novel.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Chen, Yong — Duke University
- Study coordinator: Chen, Yong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.