Investigating the link between levonorgestrel intrauterine system and temporomandibular disorders
Official title: Is the Incidence of Temporomandibular Disorder Increased in the Use of Levonorgestrel Intrauterine System
Run by Marmara University · NCT06500390 · Data updated 2026-11-12
This study is trying to see if using a specific birth control device called the levonorgestrel intrauterine system is linked to jaw joint problems in women.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 100 (estimated) |
| Sponsor | Marmara University Academic / other |
| Locations | 1 site (Istanbul, Maltepe) |
| Status | Recruiting |
| Started | January 15, 2024 |
| Main results expected | April 15, 2024 |
| Study ends | December 15, 2024 |
| Registry record updated | November 25, 2024 |
| Trial ID | NCT06500390 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women aged 18-50 who have been using a levonorgestrel intrauterine device for at least three months.
✕Probably not a fit
Patients with craniofacial syndromes, head and neck trauma history, or other specific exclusions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to explore the potential relationship between the use of the levonorgestrel intrauterine system (LIU) and the occurrence of temporomandibular joint disorders (TMD) in women. It involves two groups: one consisting of women who have used the LIU for at least three months and a control group of healthy women with regular menstrual cycles. The study will compare the frequency of temporomandibular dysfunction between these two groups to determine if there is a significant association. A total of 60 participants will be examined for their temporomandibular joint and masticator muscles.
Why it matters
Potential benefit: If successful, this study could provide insights into the safety and side effects of the levonorgestrel intrauterine system, particularly regarding its impact on temporomandibular disorders.
How similar studies have gone: While this study explores a specific association, similar studies have not extensively investigated the relationship between levonorgestrel intrauterine systems and temporomandibular disorders, making this approach relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Being a woman * Having used an intrauterine device for at least 3 months * Being between the ages of 18-50 * Being in American Society of Anesthesiologists-1 and American Society of Anesthesiologists-2 systemic status Exclusion Criteria: * Patients with craniofacial syndrome * Patients with a history of head and neck trauma * Isolated muscle tenderness or previous surgery on TMJ * Patients with rheumatological disorders * Patients with an additional gynecological disease other than endometriosis * Lack of cooperation with the patient.
Where it's running
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Marmara University
Istanbul, Maltepe, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Serhat Can, Specialist
- Email: drserhatcan@gmail.com
- Phone: +905556161166
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.