Clinical trial Recruiting at 1 site Interventional Ages 18 to 45 Women only

Investigating the link between levonorgestrel intrauterine system and temporomandibular disorders

Official title: Is the Incidence of Temporomandibular Disorder Increased in the Use of Levonorgestrel Intrauterine System

Run by Marmara University · NCT06500390 · Data updated 2026-11-12

This study is trying to see if using a specific birth control device called the levonorgestrel intrauterine system is linked to jaw joint problems in women.

More Temporomandibular Disorder trials

Quick facts

Study typeInterventional
Ages18 Years to 45 Years
SexWomen only
Enrollment100 (estimated)
SponsorMarmara University
Academic / other
Locations1 site (Istanbul, Maltepe)
StatusRecruiting
StartedJanuary 15, 2024
Main results expectedApril 15, 2024
Study endsDecember 15, 2024
Registry record updatedNovember 25, 2024
Trial IDNCT06500390 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are women aged 18-50 who have been using a levonorgestrel intrauterine device for at least three months.

Probably not a fit

Patients with craniofacial syndromes, head and neck trauma history, or other specific exclusions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to explore the potential relationship between the use of the levonorgestrel intrauterine system (LIU) and the occurrence of temporomandibular joint disorders (TMD) in women. It involves two groups: one consisting of women who have used the LIU for at least three months and a control group of healthy women with regular menstrual cycles. The study will compare the frequency of temporomandibular dysfunction between these two groups to determine if there is a significant association. A total of 60 participants will be examined for their temporomandibular joint and masticator muscles.

Why it matters

Potential benefit: If successful, this study could provide insights into the safety and side effects of the levonorgestrel intrauterine system, particularly regarding its impact on temporomandibular disorders.

How similar studies have gone: While this study explores a specific association, similar studies have not extensively investigated the relationship between levonorgestrel intrauterine systems and temporomandibular disorders, making this approach relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Being a woman
* Having used an intrauterine device for at least 3 months
* Being between the ages of 18-50
* Being in American Society of Anesthesiologists-1 and American Society of Anesthesiologists-2 systemic status

Exclusion Criteria:

* Patients with craniofacial syndrome
* Patients with a history of head and neck trauma
* Isolated muscle tenderness or previous surgery on TMJ
* Patients with rheumatological disorders
* Patients with an additional gynecological disease other than endometriosis
* Lack of cooperation with the patient.

Where it's running

  • Marmara University
    Istanbul, Maltepe, Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.