Investigating white matter fibers in the brain during wakefulness and sleep
Investigating the Functional Characteristics During Wakefulness and Sleep Based on SEEG
This study is testing how sleep affects the connections in the brain's white matter for people aged 14-65 with drug-resistant epilepsy to help improve treatment options.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 14 Years to 65 Years |
| Sex | All |
| Sponsor | Xuanwu Hospital, Beijing Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT06524479 on ClinicalTrials.gov |
What this trial studies
This study aims to analyze electrophysiological and clinical data from patients aged 14-65 with drug-resistant epilepsy who undergo stereoelectroencephalography (SEEG) to explore the functional characteristics of white matter fibers. By recording brain signals, the study seeks to understand how white matter connectivity changes between wakefulness and sleep. The research focuses on the impact of sleep on brain connectivity and its implications for epilepsy treatment. The findings could provide insights into the neuronal functional states and cortical excitability related to epilepsy.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 14-65 with drug-resistant focal epilepsy requiring SEEG exploration for presurgical assessment.
Not a fit: Patients who are pregnant or have experienced surgical complications during the implant procedure will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of brain connectivity in epilepsy, potentially leading to improved treatment strategies.
How similar studies have performed: While the approach of using SEEG to study white matter connectivity is innovative, similar studies have shown promise in understanding brain function during different states.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Drug-resistant focal epilepsy * Justified SEEG exploration in the context of presurgical assessment of epilepsy * Subjects will be a part of the epilepsy-monitoring unit for long-term SEEG recordings and analysis * Written non-opposition to study participation Exclusion Criteria: * Pregnant women (Contraindication to SEEG exploration) * Subjects that experience surgical complications during the implant procedure will be excluded from the study
Where this trial is running
Beijing, Beijing Municipality
- Xuanwu Hospital, Beijing — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Principal investigator: Liankun Ren, MD — Xuanwu Hospital, Beijing
- Study coordinator: Liankun Ren, MD
- Email: renlk2022@outlook.com
- Phone: 13681576621
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.