Biomarker study to predict Vagus Nerve Stimulation response in adults with refractory epilepsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This longitudinal study follows patients before and after VNS implantation to identify biomarkers and connectivity patterns that may predict treatment response. It uses neurophysiologic and network measures to understand how VNS works and why some patients respond better than others. The goal is to improve patient selection and personalize expectations for VNS in refractory epilepsy. The study is conducted at Clinique Universitaires Saint-Luc in Brussels and includes adults with epilepsy who are scheduled for VNS implantation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged \>18 years
* Intelectual Quotient \>55 on Wechsler scale (normal or mild cognitive impairment)
* Patients have refractory epilepsy and are planned for VNS implantation

Exclusion Criteria:

* Concomitant laryngeal pathology (e.g. recurrent nerve lesions, vocal fold paralysis).
* Dementia/ Neurodegenerative diseases

Where it's running

• Clinique Universitaires Saint-Luc
  Brussels, Belgium Recruiting

Study contacts

• Study coordinator: Riëm EL TAHRY, Pr.
• Email: riem.eltahry@uclouvain.be
• Phone: +322 764 28 55

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.