Exploring the effects of blue light on vagus nerve stimulation for epilepsy treatment
Effect of Blue Light on Vagus Nerve Stimulation in Patients With Refractory Epilepsy
This study is testing if blue light can make vagus nerve stimulation work better for people with epilepsy who still have seizures despite treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 34 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Cliniques universitaires Saint-Luc- Université Catholique de Louvain Academic / other |
| Locations | 1 site (Woluwe-Saint-Lambert) |
| Trial ID | NCT06304389 on ClinicalTrials.gov |
What this trial studies
This study investigates how exposure to blue light may enhance the effects of vagus nerve stimulation (VNS) in patients suffering from refractory epilepsy. VNS is an established treatment, but many patients do not experience sufficient relief from their seizures. By examining various biomarkers associated with VNS action, the study aims to determine if blue light can improve the efficacy of this treatment. The methodology includes the use of electroencephalography, electrocardiograms, and other assessments to monitor the effects of light exposure on patients with VNS implants.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18-60 with VNS implants for at least three months and a normal IQ or mild cognitive impairment.
Not a fit: Patients with other implanted medical devices or ocular diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved seizure control for patients with refractory epilepsy.
How similar studies have performed: While VNS is a well-established treatment, the combination with blue light exposure is a novel approach that has not been extensively tested in previous studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients: VNS implanted since at least 3 months age \>18-60 years; IQ \>55 on Wechsler scale (normal status or mild cognitive impairment) healthy participants aged between 18 and 35 years without any medical history (neurological / psychiatric disease) Exclusion criteria: Patients: other medical implanted devices than VNS, ocular diseases Helthy participants: medical implanted devices, cerebral trauma, ocular disease
Where this trial is running
Woluwe-Saint-Lambert
- Cliniques Universitaires Saint Luc — Woluwe-Saint-Lambert, Belgium (Recruiting)
Study contacts
- Study coordinator: Inci cakiroglu
- Email: inci.cakiroglu@uclouvain.be
- Phone: +32470612917
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.