Condition

Proton Therapy clinical trials and research

• 12Clinical trials
• 22NIH research projects
• 12Countries

Newest Proton Therapy clinical trials

All recruiting trials (12)

• Protoacoustic Imaging to See Radiation Delivery in Proton Therapy

  This study tests radioacoustic imaging with ultrasound to help doctors see where proton therapy is delivering radiation for liver and prostate cancer patients.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07832617

• Proton Therapy Treatment-Planning Software: Checking How Well RayStation and RayCare Work in Real Care

  This study tests whether the RayStation 2025 and RayCare 2025 software upgrades reliably support delivering standard proton therapy to adults.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07759999

• Proton total marrow irradiation before allogeneic transplant for high-risk AML or MDS

  This trial tests whether adding proton-based total marrow irradiation to standard chemotherapy conditioning before allogeneic stem cell transplant can improve outcomes for adults with high-risk or relapsed/refractory AML or MDS.

  Recruiting at 2 sites Phase 1/2 Institute of Hematology and Blood Transfusion, Czech Republic · Prague and 1 other locations · NCT07532824

• Humanitas Proton Therapy (HU-PRO) Registry

  This registry collects treatment and outcome data from adults with solid tumors who receive proton therapy to help understand safety and effectiveness.

  Recruiting Istituto Clinico Humanitas · Rozzano, Michigan · NCT07317245

• Ultra‑ vs moderately hypofractionated proton therapy after lumpectomy for early breast cancer

  This compares a very short (5-session) proton radiation schedule to a moderate (15-session) proton schedule for women 40 and older after lumpectomy for early-stage breast cancer.

  Recruiting Shanghai Proton and Heavy Ion Center · Shanghai · NCT07135661

• Comparing two types of radiation therapy for breast cancer

  This study is testing whether a new type of radiation therapy for breast cancer is safer and more effective than the standard treatment to help patients feel better and live longer.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT06826885

• Proton therapy for advanced cervical cancer

  This study is testing whether combining proton therapy with standard chemotherapy and brachytherapy can help people with advanced cervical cancer while reducing side effects.

  Recruiting Phase 2 University of Aarhus · Copenhagen · NCT06462378

• Comparing the long-term effects of proton therapy and photon radiotherapy on cognitive function in patients with cavernous sinus meningioma

  This study is testing whether proton therapy or photon radiotherapy is better at protecting brain function and improving quality of life for patients with cavernous sinus meningioma.

  Recruiting at 3 sites Centre Francois Baclesse · Caen and 12 other locations · NCT05895344

• Comparing proton and photon therapy for esophageal cancer treatment

  This study is testing if proton therapy can help people with operable esophageal cancer have fewer lung problems after treatment compared to the usual photon therapy.

  Recruiting at 8 sites Phase 3 University of Aarhus · Leuven and 14 other locations · NCT05055648

• Using virtual reality to reduce stress in children undergoing proton therapy

  This study is testing whether using virtual reality can help reduce stress and anxiety in children receiving proton therapy for cancer treatment.

  Recruiting Centre Antoine Lacassagne · Nice · NCT04934293

• Combining proton therapy and chemotherapy for borderline resectable pancreatic cancer

  This study is testing whether combining chemotherapy with proton therapy before surgery can help people with borderline resectable pancreatic cancer have better outcomes.

  Recruiting at 2 sites EBG MedAustron GmbH · Wiener Neustadt, Lower Austria and 1 other locations · NCT04894643

• Using imaging to improve proton therapy for chordomas and chondrosarcomas

  This study is testing if using advanced imaging techniques can help improve proton therapy for patients with aggressive bone tumors called chordomas and chondrosarcomas by better targeting the tumors and protecting healthy tissue.

  Recruiting at 2 sites Leiden University Medical Center · Delft, South Holland and 1 other locations · NCT04832620

NIH-funded research (22)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Intelligent and Personalized Online Adaptive Proton Therapy

  A new, AI-powered online system aims to tailor proton therapy in real time for patients with cancers near vital organs, to reduce side effects and improve outcomes.

  NIH research University of Chicago · Chicago, United States · NIH-11601037

• Efficient AI-Driven Image Guidance for Upright Lung Proton Therapy

  A patient-focused AI-powered system helps guide upright proton therapy for lung cancer to improve accuracy and accessibility.

  NIH research Stanford University · Stanford, United States · NIH-11431356

• 3D in vivo dosimetry for FLASH proton therapy

  A new protoacoustic dosimeter will help doctors precisely measure dose delivery in proton FLASH therapy for adults with cancer.

  NIH research University of California-Irvine · Irvine, United States · NIH-11393103

• Dose-LET Volume Histogram to Improve Safe Proton Therapy in Head and Neck Cancer

  A Mayo Clinic study will develop a new tool to map dose and LET in spot-scanning proton therapy to reduce severe side effects for head and neck patients.

  NIH research Mayo Clinic Arizona · Scottsdale, United States · NIH-11380816

• AI-guided proton therapy that adapts during treatment for head and neck cancer

  Using AI to build 3D images from routine X-rays so proton therapy can be updated during treatment for people with head and neck cancer.

  NIH research Mayo Clinic Arizona · Scottsdale, United States · NIH-11314566

• Real-time guided proton radiation for more precise liver tumor treatment

  Trying a proton radiation approach that tracks liver tumors in real time to treat people with liver cancer more precisely while protecting healthy liver tissue.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11294260

• Compact upright proton therapy for much faster treatments

  This project builds a smaller proton therapy beam-delivery system so people with cancer—especially children and those with moving tumors—can get treatments in seconds instead of minutes.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11294180

• Who is most likely to benefit from proton therapy to reduce treatment side effects

  This project compares proton and conventional radiation to find which patients may have fewer long-term side effects from proton therapy.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11184387

• 3-D in-body dose monitor for FLASH proton radiation

  This project is creating a 3-D in-body device that monitors the radiation dose delivered during ultra-fast 'FLASH' proton therapy for adult cancer patients.

  NIH research University of California-Irvine · Irvine, United States · NIH-11167545

• Personalized online adaptive proton therapy for cancer treatment

  This study is looking at how to make proton therapy for cancer patients even better by using smart technology that adjusts treatment plans on the spot, helping to ensure that the radiation hits the right spot even if your body changes during treatment.

  NIH research Emory University · Atlanta, United States · NIH-11159734

• Mapping proton therapy dose and radiation quality to reduce side effects

  This work creates clear 3D maps of proton dose and radiation quality to help people getting brain or head-and-neck proton therapy have safer treatment.

  NIH research Mayo Clinic Arizona · Scottsdale, United States · NIH-11146356

• Improving proton therapy for cancer treatment using artificial intelligence

  This study is testing a new way to make proton therapy for head and neck cancer even better by using artificial intelligence to adjust treatment plans on the spot, helping to ensure that patients get the most accurate and effective care as their bodies change during treatment.

  NIH research Mayo Clinic Arizona · Scottsdale, United States · NIH-11132246

• A new platform for advanced proton therapy in lung cancer treatment

  This study is looking at a new way to make proton therapy for central lung cancer safer and more effective, so patients can get better treatment with fewer side effects.

  NIH research Emory University · Atlanta, United States · NIH-11122784

• Developing a new system for faster proton therapy treatment

  This study is working on a new way to deliver proton therapy quickly and efficiently, especially for kids with cancer, so that treatments are faster and more comfortable for patients.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11045771

• Improving proton therapy for liver cancer treatment

  This study is looking at a new way to make proton therapy for liver cancer even better by using special imaging to track tumors in real-time, helping doctors deliver radiation more accurately while protecting healthy tissue, so patients can have a safer and more effective treatment experience.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10993207

• Improving proton therapy to better protect healthy tissues during cancer treatment

  This study is testing a new way to make proton therapy for cancer even better by adjusting the radiation beam in real-time, which could help more patients with brain tumors or head and neck cancers get more effective treatment while protecting healthy tissues.

  NIH research University of Iowa · Iowa City, United States · NIH-10930925

• Investigating how normal tissue reacts to proton therapy compared to traditional radiation.

  This study is looking at how different types of radiation therapy, like proton therapy and regular photon therapy, affect healthy tissues in the body, so we can find out which patients might get the best results from proton therapy and create more tailored treatment plans for them.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10929958

• Using exosomal RNA to improve prostate cancer proton therapy outcomes

  This study is looking at how tiny particles in your body called exosomes can help us see how well proton therapy is working for treating prostate cancer, especially for African American patients, by checking changes in their RNA before and after treatment.

  NIH research Hampton University · Hampton, United States · NIH-10925185

• A compact proton therapy system for cancer treatment

  This study is looking at a new, smaller machine for proton therapy that can fit into existing cancer treatment centers, making it easier for patients in cities to get this advanced cancer treatment.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10855497

• Developing a new tool for measuring radiation doses in cancer treatment

  This study is working on a new device that will help doctors measure radiation levels during a special cancer treatment called proton FLASH therapy, making sure tumors get the right dose while protecting healthy tissue, and it aims to be ready for use in hospitals in the next 5-10 years.

  NIH research University of California-Irvine · Irvine, United States · NIH-10849547

• Improving safety in proton therapy for head and neck cancer

  This study is looking for ways to make proton therapy safer for people with head and neck cancer by creating a new tool that helps doctors see how radiation affects different parts of the body, so they can better protect healthy tissues while treating the cancer.

  NIH research Mayo Clinic Arizona · Scottsdale, United States · NIH-10800540

• Improving accuracy in proton therapy using advanced detectors

  This study is looking to make proton therapy for cancer even better by creating special detectors that help doctors see exactly where the treatment is going in real-time, which is especially important for patients with tumors near vital organs.

  NIH research University of California at Davis · Davis, United States · NIH-10767799

Related topics

Quick answers

How many Proton Therapy clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in France (3 trials), China (2 trials), Denmark (2 trials), Italy (2 trials), Netherlands (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Phase 3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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