Developing a new tool for measuring radiation doses in cancer treatment
Official title: 3D In vivo dosimetry for FLASH proton therapy
Funded at University of California-Irvine · NIH-10849547 · Data updated 2026-11-12
This study is working on a new device that will help doctors measure radiation levels during a special cancer treatment called proton FLASH therapy, making sure tumors get the right dose while protecting healthy tissue, and it aims to be ready for use in hospitals in the next 5-10 years.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | August 12, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $641,155 |
| NIH project number | 1U01CA288351-01 |
| Project ID | NIH-10849547 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients who are undergoing proton FLASH therapy.
✕Less likely to help
Patients who are not receiving radiation therapy or those with conditions that do not involve proton FLASH therapy may not benefit from this research.
What this research studies
This research focuses on creating a new type of dosimeter that can accurately measure radiation doses during proton FLASH therapy, a cutting-edge cancer treatment that delivers high doses of radiation quickly. The project aims to ensure that the right amount of radiation is delivered to tumors while minimizing damage to surrounding healthy tissues. By forming a collaborative team of experts from various fields, the research seeks to bring this innovative dosimeter into clinical use within the next 5-10 years, addressing a critical need in cancer care.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective cancer treatments by improving the precision of radiation delivery.
How similar studies have gone: While the approach of using protoacoustic imaging for dosimetry is innovative, similar research in radiation therapy has shown promise in improving treatment accuracy.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Xiang, Liangzhong Shawn — University of California-Irvine
- Study coordinator: Xiang, Liangzhong Shawn
Related research
Other NIH-funded projects on the same topics.
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Intelligent and Personalized Online Adaptive Proton Therapy
A new, AI-powered online system aims to tailor proton therapy in real time for patients with cancers near vital organs, to reduce side effects and improve outcomes.
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Efficient AI-Driven Image Guidance for Upright Lung Proton Therapy
A patient-focused AI-powered system helps guide upright proton therapy for lung cancer to improve accuracy and accessibility.
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3D in vivo dosimetry for FLASH proton therapy
A new protoacoustic dosimeter will help doctors precisely measure dose delivery in proton FLASH therapy for adults with cancer.
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Dose-LET Volume Histogram to Improve Safe Proton Therapy in Head and Neck Cancer
A Mayo Clinic study will develop a new tool to map dose and LET in spot-scanning proton therapy to reduce severe side effects for head and neck patients.
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AI-guided proton therapy that adapts during treatment for head and neck cancer
Using AI to build 3D images from routine X-rays so proton therapy can be updated during treatment for people with head and neck cancer.
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Real-time guided proton radiation for more precise liver tumor treatment
Trying a proton radiation approach that tracks liver tumors in real time to treat people with liver cancer more precisely while protecting healthy liver tissue.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.