Care patterns for elderly patients with head and neck cancer receiving radiotherapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the oncological outcomes of elderly patients (aged 65 and older) with locally advanced head and neck squamous cell carcinoma (HNSCC) who are undergoing definitive (chemo-)radiotherapy. It will analyze the impact of concomitant chemotherapy on overall survival and progression-free survival while adjusting for confounding factors such as age and performance status. The study will utilize data from multiple centers to provide insights into the effectiveness of modern radiotherapy techniques and supportive treatments in this vulnerable patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* definitive (chemo-)radiotherapy of locoregionally advanced (cT3-4 and/or cN+) head-and-neck squamous cell carcinomas (HNSCC) of the oral cavity, oropharynx, hypopharynx or larynx
* primary treatment since 2005
* age ≥65 years at the time of (chemo-)radiotherapy

Exclusion Criteria:

* adjuvant (chemo-)radiotherapy
* history of previous head-and-neck cancers or radiotherapy in the head-and-neck region
* distant metastases at (chemo-)radiotherapy initiation (cM1)
* HNSCCs of the nasopharynx, salivary glands, skin or with unknown primary

Where it's running

• Jena University Hospital
  Jena, Germany Recruiting
• Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine
  Baltimore, Maryland, United States Completed
• Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai
  New York, New York, United States Completed
• Department of Radiation Oncology, Case Western Reserve University
  Cleveland, Ohio, United States Completed
• Division of Radiation Oncology, The Ohio State University Wexner
  Columbus, Ohio, United States Completed
• Radiation Oncology Department, German Oncology Center
  Limassol, Cyprus Completed

Study contacts

• Principal investigator: Nils H. Nicolay, MD, PhD — Department of Radiation Oncology, Medical Center - University of Freiburg
• Study coordinator: Alexander Rühle, MD, MHBA
• Email: alexander.ruehle@uniklinik-freiburg.de
• Phone: 004976127095200

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.