Detecting HPV-related throat cancer earlier in people with and without HIV

Who could benefit from this research

What this research studies

This research focuses on improving the early detection of HPV-related oropharynx cancer (HPV-OPC), particularly in individuals living with HIV, who are at a higher risk. The study will utilize a large cohort of participants to screen for specific oral and blood biomarkers associated with HPV-OPC. By comparing the progression of the disease in those with and without HIV, the research aims to enhance understanding of how HIV affects HPV persistence and cancer development. The findings could lead to better screening methods and inform future studies on the benefits and risks of such screenings.

Why it matters

Where this research is happening

• Johns Hopkins University
  Baltimore, United States Active

Researchers

• Principal investigator: Fakhry, Carole — Johns Hopkins University
• Study coordinator: Fakhry, Carole

Related research

Other NIH-funded projects on the same topics.

• An image-based test to predict risk in HPV-positive throat cancer

  This project aims to develop a simple image- and molecular-based test to show which people with HPV-positive oropharynx (throat) cancer are more likely to have a recurrence so their treatment can be personalized.

  NIH research Washington University · Saint Louis, United States · NIH-11469884

• A new tumor marker (HPVhet) to predict outcomes in HPV-related throat cancer

  This project looks at whether a tumor marker called HPVhet can better predict which people with HPV-positive throat cancer will do well and which might need stronger treatment.

  NIH research Washington University · Saint Louis, United States · NIH-11469883

• Neoadjuvant immunoradiotherapy for HPV-related throat cancer

  A new approach combines targeted radiation before surgery with PD-1 blockade to treat HPV-related oropharyngeal cancer, aiming to improve outcomes and reduce long-term side effects.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11377117

• A test to predict outcomes for HPV-positive oropharynx (throat) cancer using tumor molecular and imaging features

  This project will see if an 'HPVhet' score derived from tumor biology and routine pathology images can help predict outcomes for people with HPV-positive oropharynx cancer.

  NIH research Washington University · Saint Louis, United States · NIH-11301847

• Improving treatment for HPV-related throat cancer before surgery

  This research explores a new way to combine radiation and immunotherapy before surgery for people with HPV-related throat cancer.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11146417

• Finding a new way to predict outcomes for patients with oropharynx cancer

  This study is looking to find a new way to help doctors predict how oropharynx cancer might affect patients, especially those with HPV-positive tumors, so they can tailor treatments better and avoid giving unnecessary side effects to those who might not need them.

  NIH research Washington University · Saint Louis, United States · NIH-11040101

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.