Condition

Oral Cavity Cancer clinical trials and research

• 12Clinical trials
• 2NIH research projects
• 8Countries

Newest Oral Cavity Cancer clinical trials

All recruiting trials (12)

• Biomarkers for oral cavity cancer response to neoadjuvant immunotherapy using patient-specific tumor cultures

  This will test whether a patient-specific tumor culture can predict how people with oral cavity cancer respond to pembrolizumab given before surgery.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07343596

• Neoadjuvant chemoimmunotherapy with PD-1 blockade to reduce surgery for advanced head and neck cancer

  This approach will try a short course of chemotherapy plus the PD-1 drug toripalimab before standard treatment for people with advanced head and neck cancers to shrink tumors and allow less extensive surgery or radiation.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT07209189

• Sacituzumab govitecan plus cetuximab for recurrent or metastatic head and neck squamous cell cancer

  This trial will test whether combining sacituzumab govitecan with cetuximab works and is safe for people whose head and neck squamous cell cancer has returned or spread after prior immunotherapy.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07063212

• Comparing navigation support to standard care for starting radiation therapy in head and neck cancer patients

  This study is testing a new support program to help people with head and neck cancer start their radiation therapy on time compared to the usual care they receive.

  Recruiting at 4 sites Medical University of South Carolina · St Louis, Missouri and 3 other locations · NCT05793151

• New surgical procedure for reconstructing the oral cavity and oropharynx in cancer patients

  This study is testing a new surgical method using a special tissue flap to see if it can safely help cancer patients who need reconstruction in their mouth and throat areas.

  Recruiting at 2 sites Institut Claudius Regaud · Montpellier and 3 other locations · NCT05757817

• Comparing methods for closing the radial forearm donor site after surgery

  This study is testing two different ways to close the arm after surgery for head and neck reconstruction to see which method helps patients heal better and feel happier with their results.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT05740033

• Improving jaw reconstruction for oral cancer patients using virtual planning

  This study is testing if using virtual planning for jaw surgery can help oral cancer patients heal better and have a better quality of life compared to traditional surgery methods.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT05429099

• Study of immune biomarkers in head and neck cancer

  This study is testing if certain immune markers in patients with newly diagnosed head and neck cancer can help predict their treatment outcomes and guide their care.

  Recruiting at 3 sites University of Erlangen-Nürnberg Medical School · Erlangen, Bavaria and 2 other locations · NCT05375266

• Care patterns for elderly patients with head and neck cancer receiving radiotherapy

  This study is looking at how well elderly patients with advanced head and neck cancer do with radiation treatment and chemotherapy to see if it helps them live longer and stay healthier.

  Recruiting University Hospital Freiburg · Baltimore, Maryland and 17 other locations · NCT05337631

• Comparing gross examinations and frozen sections for surgical margins in oral cancers

  This study is testing whether using frozen section analysis during surgery helps patients with oral cancer have better outcomes compared to just looking at the tissue with the naked eye.

  Recruiting at 3 sites Tata Memorial Centre · Mumbai, Maharashtra and 2 other locations · NCT04809324

• A resource for collecting cancer data and biospecimens

  This study is creating a resource to collect health information and samples from cancer patients and healthy individuals to help improve cancer prevention and treatment strategies.

  Recruiting at 42 sites University of Nebraska · Greenwood Village, Colorado and 41 other locations · NCT02012699

• Screening for oral cavity cancer in smokers

  This study is trying to see if educating doctors and encouraging smokers in their 30s to 75s to get checked can help catch oral cancers earlier in a region where these cancers are common.

  Recruiting at 2 sites Centre Hospitalier Universitaire, Amiens · Amiens, Picardie and 1 other locations · NCT01958762

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• AI-powered chairside chip test to detect precancer and early oral cancer during dental and medical visits

  A small chip-based cell test using AI to help dentists and doctors spot precancerous changes and early oral cancer in people with suspicious mouth lesions or a history of oral cancer.

  NIH research New York University · New York, United States · NIH-11301800

• Investigating oral dysplasia and cancer risk using a new diagnostic tool

  This study is testing a new, easy-to-use tool that helps doctors quickly and safely check for early signs of mouth cancer in patients who have had oral cancer or certain mouth conditions, with the hope of catching problems sooner and improving treatment outcomes.

  NIH research New York University · New York, United States · NIH-11035065

Related topics

Quick answers

How many Oral Cavity Cancer clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (6 trials), France (2 trials), Germany (2 trials), Canada (2 trials), India (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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