Condition

Opioid clinical trials and research

• 9Clinical trials
• 1New in 30 days
• 7Countries

Newest Opioid clinical trials

All recruiting trials (9)

• Dexmedetomidine as add-on for refractory cancer pain in palliative care

  This study tests whether adding dexmedetomidine helps improve pain control for adults with cancer in palliative care whose pain remains high despite opioids.

  Recruiting St. Olavs Hospital · Drammen and 3 other locations · NCT07885475

• How MOR Activation Affects Stress and Social Behavior, and How Childhood Unpredictability Modulates This in Men and Women

  This study tests whether activating the mu opioid receptor with morphine changes stress responses and social behavior, and whether sex and early life unpredictability alter those effects.

  Recruiting Psychiatric University Hospital, Zurich · Zurich · NCT07778511

• Opioid-free versus usual discharge pain plans after major orthopedic surgery.

  This pilot trial will test whether sending adults home after major orthopedic surgery with an opioid-free pain prescription provides pain control similar to the usual opioid-containing prescription.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07265557

• Erector spinae block to lower opioid use after total abdominal hysterectomy

  This will test whether giving an erector spinae nerve block during general anesthesia can reduce opioid use for people having an elective total abdominal hysterectomy.

  Recruiting Phase 4 Kulsoom International Hospital · Islamabad, Federal · NCT07178262

• Using virtual reality to reduce opioid use after heart and thoracic operations

  This study will test whether adding virtual reality sessions after cardiac or thoracic surgery can lower opioid use in patients aged 16–40.

  Recruiting Instituto do Coracao · São Paulo, São Paulo · NCT07063394

• Whether intense pain before emergency surgery leads to long-term pain after the operation

  We will test whether people having emergency abdominal or orthopedic surgery who have strong pain before the operation are more likely to have ongoing pain three months afterward.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT06555107

• Using semaglutide to help reduce opioid use in patients undergoing treatment for opioid use disorder

  This study is testing if the medication semaglutide can help adults in outpatient treatment for opioid use disorder reduce their use of illicit opioids.

  Recruiting at 3 sites Phase 2 Milton S. Hershey Medical Center · Baltimore, Maryland and 3 other locations · NCT06548490

• Using low-dose ketamine to relieve pain during burn wound care

  This study is testing if low-dose ketamine can help relieve pain better than standard opioid treatments during wound care for people with burn injuries.

  Recruiting Phase 4 University of Tennessee · Memphis, Tennessee · NCT06506565

• Ketamine improves pain relief and mood in chronic pain patients

  This study is testing whether Ketamine injections can help people with chronic pain and mood disorders feel better both physically and emotionally.

  Recruiting Salem Anaesthesia Pain Clinic · Surrey, British Columbia · NCT05985811

Related topics

Quick answers

How many Opioid clinical trials are recruiting right now?

9, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (3 trials), France (1 trial), Brazil (1 trial), Switzerland (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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