Erector spinae block to lower opioid use after total abdominal hysterectomy
Opioid Sparing Effect of Erector Spinae Block in Patients Undergoing Total Abdominal Hysterectomy; A Randomized Control Trial
This will test whether giving an erector spinae nerve block during general anesthesia can reduce opioid use for people having an elective total abdominal hysterectomy.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 16 Years to 80 Years |
| Sex | Female |
| Sponsor | Kulsoom International Hospital Academic / other |
| Locations | 1 site (Islamabad, Federal) |
| Trial ID | NCT07178262 on ClinicalTrials.gov |
What this trial studies
Total abdominal hysterectomy causes substantial postoperative pain and often requires high perioperative opioid doses, which can slow recovery due to nausea, vomiting, constipation, and respiratory depression. In this interventional Phase 4 protocol, participants undergoing elective total abdominal hysterectomy receive either an erector spinae plane (ESP) block with bupivacaine or a placebo block in the perioperative period. Opioid consumption after surgery, along with common opioid-related side effects and recovery measures, will be recorded and compared between groups. Eligible patients are adults classified as ASA I–III having elective procedures at the study hospital.
Who should consider this trial
Good fit: Ideal candidates are adults (ASA class I–III) scheduled for elective total abdominal hysterectomy who can consent and do not have chronic opioid use or other exclusion criteria.
Not a fit: Patients with chronic pain, active opioid misuse or addiction, allergy to local anesthetics, or BMI over 35 are excluded and unlikely to gain benefit from this protocol.
Why it matters
Potential benefit: If successful, the ESP block could reduce perioperative opioid use and related side effects, helping patients recover more comfortably after hysterectomy.
How similar studies have performed: Fascial plane blocks including ESP and related regional techniques have shown reductions in postoperative opioid use in several surgical settings, but evidence is still emerging and varies by procedure.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists (ASA) class: I, II and III . * Elective Hysterectomy under General Anesthesia. Exclusion Criteria: * Lack of consent * Body mass index \>35 kg/m2 * Allergic to study medicine * Opioid abuse or misuse disorder * Chronic pain
Where this trial is running
Islamabad, Federal
- Kulsoom Internation Hospital — Islamabad, Federal, Pakistan (Recruiting)
Study contacts
- Study coordinator: Waqas Anjum, Principal Investigator, MBBS, FCPS
- Email: waqasanjum435@gmail.com
- Phone: +92-310-3308158
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.