Condition

Narcolepsy clinical trials and research

• 13Clinical trials
• 4NIH research projects
• 12Countries

Newest Narcolepsy clinical trials

All recruiting trials (13)

• HBS-301 for Narcolepsy: daily wakefulness and sleepiness improvement in adults

  This Phase 3 study tests HBS-301 vs placebo in adults with narcolepsy to see if it helps with daytime sleepiness, cataplexy, sleepiness, and fatigue.

  Recruiting at 29 sites Phase 3 Harmony Biosciences Management, Inc. · Birmingham, Alabama and 52 other locations · NCT07675135

• Expanded-dosing Xywav vs placebo in narcolepsy and IH

  This study tests whether expanded nightly dosing of Xywav helps adults with narcolepsy or idiopathic hypersomnia, compared with placebo.

  Recruiting at 15 sites Phase 3 Jazz Pharmaceuticals · Birmingham, Alabama and 14 other locations · NCT07625280

• Testing Lu AH69593 for safety and tolerance in healthy adults and people with narcolepsy

  This study tests whether Lu AH69593 is safe and well tolerated in adults, including those with narcolepsy, and looks at how the body processes the drug with and without food.

  Recruiting Phase 1 H. Lundbeck A/S · Helsinki and 1 other locations · NCT07613710

• Samelisant for Narcolepsy: A Phase 3 Test for EDS and Cataplexy

  This phase 3 study tests whether Samelisant can reduce daytime sleepiness and cataplexy in adults with narcolepsy.

  Recruiting Phase 3 Suven Life Sciences Limited · Columbia, South Carolina · NCT07540364

• E2086 for adults with narcolepsy: find the best dose compared with placebo

  This study tests different doses of E2086 against placebo in adults with narcolepsy to see if it reduces daytime sleepiness.

  Recruiting at 2 sites Phase 2 Eisai Inc. · Santa Ana, California and 56 other locations · NCT07493265

• Exploring the effects of light and electrical stimulation on sleep disorders

  This study is testing if light therapy and brain stimulation can help people with sleep disorders like insomnia and narcolepsy get better sleep.

  Recruiting Second Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT06797284

• Registry to evaluate the safety of SUNOSI during pregnancy

  This study is trying to see if the medication SUNOSI is safe for pregnant women who have narcolepsy or sleep apnea and how it affects their babies.

  Recruiting at 2 sites Axsome Therapeutics, Inc. · Morrisville, North Carolina and 1 other locations · NCT06413420

• See if a non-drug therapy reduces nightmares in adults with narcolepsy

  This study tests a talking-based therapy called imagery rehearsal therapy to see if it reduces frequent nightmares in adults with narcolepsy, with participants and sometimes their sleep partners involved in assessments.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06383806

• Analyzing body fluids in narcolepsy patients

  This study looks at body fluids from people with narcolepsy and healthy volunteers to see if there are any unique markers that could help better understand the condition.

  Recruiting Qilu Hospital of Shandong University · Jinan, Shandong · NCT06279247

• How people with narcolepsy or idiopathic hypersomnia think socially

  This study tests social-cognition in adults with type 1 or type 2 narcolepsy or idiopathic hypersomnia using a questionnaire.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT05773872

• Registry to evaluate pitolisant use during pregnancy

  This study is trying to see how using pitolisant during pregnancy affects mothers and their babies, and it's open to pregnant women with and without narcolepsy.

  Recruiting Harmony Biosciences Management, Inc. · Morrisville, North Carolina · NCT05536011

• Registry of patients with sleep disorders

  This study is collecting information from people with sleep disorders to see how these conditions affect their lives and to track their progress over time.

  Recruiting Johannes Gutenberg University Mainz · Mainz, Rhineland-Palatinate · NCT05321355

• A platform for collecting health data on ME/CFS and Long Covid

  This study is trying to collect health information from adults with ME/CFS and Long Covid to help researchers better understand these conditions and improve future treatments.

  Recruiting Brain Inflammation Collaborative · Delafield, Wisconsin · NCT04806620

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Lateral hypothalamic neurotensin neurons and narcolepsy symptoms

  Aims to see if activating specific brain cells in the lateral hypothalamus can reduce sleepiness and cataplexy in narcolepsy models.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11514439

• Using genetics to reduce misdiagnosis of narcolepsy and sleep-wake rhythm disorders

  Researchers will create genetic risk scores that work across ancestries to help people with suspected narcolepsy and circadian rhythm sleep-wake disorders get diagnosed more accurately.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11261119

• Using genetics to improve diagnosis of narcolepsy and sleep disorders.

  This study is working to make it easier and faster for people with narcolepsy and sleep-wake disorders to get the right diagnosis by using genetic tests that are affordable and can help everyone, no matter their background.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11051238

• Understanding the brain mechanisms behind narcolepsy and cataplexy

  This study is looking at how certain parts of the brain and chemicals in our body affect sleep and sudden muscle weakness in people with narcolepsy, hoping to find out more about what causes these issues so we can better understand and help those who experience them.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11035074

Related topics

Quick answers

How many Narcolepsy clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (8 trials), China (3 trials), Germany (2 trials), Canada (2 trials), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 1: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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