Condition

Idiopathic Hypersomnia clinical trials and research

• 14Clinical trials
• 2NIH research projects
• 14Countries

Newest Idiopathic Hypersomnia clinical trials

All recruiting trials (14)

• Long-term test of TAK-360 in people with narcolepsy or idiopathic hypersomnia

  This study tests TAK-360 over an extended period to see if it is tolerable for people with narcolepsy type 1, narcolepsy type 2, or idiopathic hypersomnia who completed an earlier TAK-360 trial.

  Recruiting at 33 sites Phase 2/3 Takeda · Chula Vista, California and 32 other locations · NCT07646678

• Expanded-dosing Xywav vs placebo in narcolepsy and IH

  This study tests whether expanded nightly dosing of Xywav helps adults with narcolepsy or idiopathic hypersomnia, compared with placebo.

  Recruiting at 15 sites Phase 3 Jazz Pharmaceuticals · Birmingham, Alabama and 14 other locations · NCT07625280

• Phase 3 HBS-301 for idiopathic hypersomnia

  This trial will test whether the oral medicine HBS-301 helps adults with idiopathic hypersomnia reduce daytime sleepiness, sleep inertia, and fatigue.

  Recruiting at 42 sites Phase 3 Harmony Biosciences Management, Inc. · Birmingham, Alabama and 41 other locations · NCT07500090

• Long-term ORX750 treatment for people with narcolepsy or idiopathic hypersomnia

  This open-label extension will try continued ORX750 treatment in people with narcolepsy or idiopathic hypersomnia who completed the earlier ORX750 parent study.

  Recruiting at 24 sites Phase 2 Centessa Pharmaceuticals (UK) Limited · Auburn, Alabama and 23 other locations · NCT07096674

• Diet changes to reduce sleepiness in narcolepsy and idiopathic hypersomnia

  This project will try whether a 12-week whole-food ketogenic diet versus an isocaloric standard whole-food diet reduces daytime sleepiness and improves quality of life in adults with narcolepsy or idiopathic hypersomnia.

  Recruiting University of Sydney · Macquarie Park, New South Wales · NCT07006233

• Evaluating TAK-360 for daytime sleepiness in adults with Idiopathic Hypersomnia

  This study is testing a new medication called TAK-360 to see if it can help adults with Idiopathic Hypersomnia feel less sleepy during the day.

  Recruiting at 28 sites Phase 2 Takeda · Redwood City, California and 28 other locations · NCT06812078

• Long-term treatment with ALKS 2680 for narcolepsy and idiopathic hypersomnia

  This study is testing how well a new medication called ALKS 2680 works for people with narcolepsy or idiopathic hypersomnia over a long period of time.

  Recruiting at 50 sites Phase 2/3 Alkermes, Inc. · Cullman, Alabama and 49 other locations · NCT06767683

• Testing ORX750 for Narcolepsy and Idiopathic Hypersomnia

  This study is testing a new medication called ORX750 to see if it can help people with narcolepsy or idiopathic hypersomnia feel more awake and improve their daily lives.

  Recruiting at 37 sites Phase 2 Centessa Pharmaceuticals plc · Auburn, Alabama and 36 other locations · NCT06752668

• Understanding how food intake affects sleep in narcolepsy and hypersomnia patients

  This study is testing how what people eat affects their sleep and daytime sleepiness in patients with narcolepsy and hypersomnia to find better ways to manage their health.

  Recruiting Hospices Civils de Lyon · Clermont-Ferrand and 1 other locations · NCT06484348

• Exploring mind-wandering and its effects in narcolepsy and hypersomnolence

  This study is testing how daydreaming affects thinking and creativity in people with narcolepsy and excessive sleepiness.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06457945

• Evening melatonin plus morning bright light for idiopathic hypersomnia

  This trial will test whether taking melatonin at night and using bright light in the morning reduces daytime sleepiness and long sleep times in adults with idiopathic hypersomnia.

  Recruiting Phase 2 University Hospital, Strasbourg, France · Strasbourg · NCT06252571

• Using low sodium oxybate to improve sleep in patients with idiopathic hypersomnia

  This study is testing if low sodium oxybate can help people with idiopathic hypersomnia sleep better and stay asleep longer.

  Recruiting at 4 sites Phase 4 Mayo Clinic · Phoenix, Arizona and 3 other locations · NCT05837091

• Registry of patients with sleep disorders

  This study is collecting information from people with sleep disorders to see how these conditions affect their lives and to track their progress over time.

  Recruiting Johannes Gutenberg University Mainz · Mainz, Rhineland-Palatinate · NCT05321355

• Registry for patients with rare diseases

  This study is creating a central registry for people with rare diseases to help connect them with researchers and improve treatments.

  Recruiting Sanford Health · Sioux Falls, South Dakota · NCT01793168

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Nocturnal Sleep Signature for Diagnosing Idiopathic Hypersomnia

  A study to develop an objective sleep-based biomarker to diagnose idiopathic hypersomnia in adolescents.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11332289

• Creating a new way to diagnose idiopathic hypersomnia using sleep patterns

  This study is looking to find a new way to diagnose idiopathic hypersomnia, a condition that makes you feel really sleepy during the day, by identifying specific biological markers in your sleep patterns, so that people can get the right help more easily.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11083750

Related topics

Quick answers

How many Idiopathic Hypersomnia clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (9 trials), France (6 trials), Italy (4 trials), Spain (4 trials), Canada (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 2/3: 2, Phase 3: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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