Understanding the brain mechanisms behind narcolepsy and cataplexy
Monoaminergic and limbic systems underlying narcolepsy-cataplexy
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11035074
This study is looking at how certain parts of the brain and chemicals in our body affect sleep and sudden muscle weakness in people with narcolepsy, hoping to find out more about what causes these issues so we can better understand and help those who experience them.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11035074 on ClinicalTrials.gov |
What this research studies
This research investigates how specific brain regions and neurotransmitters are involved in the regulation of sleep and arousal in patients with narcolepsy. It focuses on the role of the limbic system and monoaminergic systems in causing cataplexy, a condition where patients experience sudden muscle weakness triggered by strong emotions. By studying the dynamics of dopamine and norepinephrine release in key brain areas, the research aims to uncover the underlying mechanisms that lead to disrupted sleep and cataplexy. This could involve both animal models and advanced neurobiological techniques to gather insights into these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with narcolepsy, particularly those experiencing cataplexy.
Not a fit: Patients with narcolepsy who do not experience cataplexy or those with other unrelated sleep disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for narcolepsy and cataplexy, enhancing the quality of life for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding the neurobiological mechanisms of sleep disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TOTH, BRANDON ANTHONY — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: TOTH, BRANDON ANTHONY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.