Condition
MSI-H clinical trials and research
As of November 12, 2026, Find a Trial lists 3 MSI-H clinical trials that are recruiting, at sites in 3 countries (most in China (1), United States (1), France (1)). By phase: Phase 2 (1), Phase 1 (1), Phase 3 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 3Countries
Newest MSI-H clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Direct injection of a modified vaccinia virus (vvDD-hIL2) into abdominal and gastrointestinal tumors | Phase 1 | Pittsburgh, Pennsylvania | Recruiting | Jun 3, 2025 |
| Using immune checkpoint inhibitors to preserve organs in non-metastatic gastric or colon cancers | Phase 2 | Beijing, Beijing Municipality | Recruiting | Aug 30, 2024 |
| Combining two immunotherapy drugs for MSI-H/dMMR advanced stomach and gastroesophageal junction cancer | Phase 3 | Brest and 6 other locations | Recruiting | Apr 3, 2024 |
All recruiting trials (3)
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Direct injection of a modified vaccinia virus (vvDD-hIL2) into abdominal and gastrointestinal tumors
This trial will try a single direct injection of a modified vaccinia virus (vvDD-hIL2) into abdominal tumors to see if it is safe for adults with advanced metastatic gastrointestinal or peritoneal cancers who have not responded to standard treatments.
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Using immune checkpoint inhibitors to preserve organs in non-metastatic gastric or colon cancers
This study is testing a new combination of immune treatments to see if it can help people with non-metastatic gastric or colon cancers keep their organs and improve their health before surgery.
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Combining two immunotherapy drugs for MSI-H/dMMR advanced stomach and gastroesophageal junction cancer
This trial will try two immunotherapy drugs (balstilimab and botensilimab) as first treatment for adults with MSI‑H/dMMR, HER2‑negative advanced or metastatic stomach or gastroesophageal‑junction cancer whose tumors have PD‑L1 CPS ≥5, and will compare that to standard chemotherapy with nivolumab.
Related topics
Quick answers
How many MSI-H clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 3 countries. The most sites are in China (1 trial), United States (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 1, Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.