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MSS clinical trials and research

• 5Clinical trials
• 2Countries

Newest MSS clinical trials

All recruiting trials (5)

• Short-course radiotherapy plus intensified chemotherapy and targeted therapy with immunotherapy for high-risk rectal cancer

  This trial tests whether adding targeted therapy and a PD-1 inhibitor to a short course of radiotherapy and standard chemotherapy helps high-risk pMMR/MSS rectal cancer patients, compared with the same radiotherapy and chemotherapy alone.

  Recruiting Phase 3 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT07549399

• Direct injection of a modified vaccinia virus (vvDD-hIL2) into abdominal and gastrointestinal tumors

  This trial will try a single direct injection of a modified vaccinia virus (vvDD-hIL2) into abdominal tumors to see if it is safe for adults with advanced metastatic gastrointestinal or peritoneal cancers who have not responded to standard treatments.

  Recruiting Phase 1 Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Pittsburgh, Pennsylvania · NCT07001592

• Short-course radiation plus CAPEOX chemotherapy and serplulimab for MSS/pMMR rectal cancer with limited metastases

  This trial will try combining short-course radiotherapy, CAPEOX chemotherapy, and the immunotherapy serplulimab to see if it helps people with MSS/pMMR rectal cancer who have a small number of metastases.

  Recruiting Phase 2 First Affiliated Hospital of Zhejiang University · Hangzhou, Zhejiang · NCT06850103

• Combination treatment for metastatic colorectal cancer

  This study is testing a combination of three drugs to see if it can help patients with certain types of metastatic colorectal cancer who have previously responded well to similar treatments.

  Recruiting Phase 2 Beijing Hospital · Beijing, Beijing Municipality · NCT06321081

• Neoadjuvant treatment for locally advanced rectal cancer using Serplulimab, CAPEOX, and Celecoxib

  This study is testing a new treatment combining an immune therapy and chemotherapy to see if it can help people with locally advanced rectal cancer before surgery.

  Recruiting Phase 2 Zhejiang University · Hangzhou, Zhejiang · NCT05731726

Related topics

Quick answers

How many MSS clinical trials are recruiting right now?

5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in China (4 trials), United States (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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