Drug or treatment

Balstilimab clinical trials

• 15Clinical trials
• 3Countries

Newest trials

All recruiting trials (15)

• Botensilimab + Balstilimab before surgery for early MSS rectal cancer

  This study tests whether giving a single dose of botensilimab followed by balstilimab can shrink MSS/pMMR early rectal tumors so some patients can avoid surgery.

  Recruiting at 2 sites Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts and 2 other locations · NCT07735624

• Neoadjuvant Botensilimab and Balstilimab for Advanced Resectable Colorectal Cancer

  This phase 2 trial tests whether giving botensilimab and balstilimab before surgery can help patients with advanced, resectable colorectal cancer see better outcomes.

  Recruiting at 11 sites Phase 2 City of Hope Medical Center · Goodyear, Arizona and 10 other locations · NCT07595874

• Combining botensilimab and balstilimab after standard treatment for colorectal cancer

  This phase 2 trial tests whether giving botensilimab and balstilimab after standard therapy can clear detectable ctDNA in adults with stage II/III colorectal cancer.

  Recruiting at 2 sites Phase 2 National Cancer Institute (NCI) · New Orleans, Louisiana and 1 other locations · NCT07551596

• Combination of balstilimab, botensilimab, and agenT-797 in pMMR colorectal cancer with liver metastases

  This trial tests whether a three-drug combination can help adults with metastatic, MSS colorectal cancer that has spread to the liver.

  Recruiting Phase 2 Scripps Health · La Jolla, California · NCT07550088

• Neoadjuvant immunotherapy with botensilimab and balstilimab for high-risk non-metastatic clear cell RCC

  This trial tests whether giving botensilimab and balstilimab before kidney tumor surgery is safe and helps patients with high‑risk non‑metastatic clear cell RCC proceed to nephrectomy.

  Recruiting at 5 sites Phase 2 National Cancer Institute (NCI) · Irvine, California and 4 other locations · NCT07516366

• Botensilimab plus balstilimab followed by balstilimab for colorectal cancer with detectable ctDNA after surgery and chemotherapy

  This trial tests whether giving botensilimab with balstilimab, then continuing balstilimab alone, helps people with microsatellite-stable colorectal cancer or colorectal liver metastases who still have detectable ctDNA after surgery and chemotherapy.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07227636

• Botensilimab and balstilimab plus SBRT for liver‑metastatic colorectal cancer

  This tests whether adding two immune drugs, botensilimab and balstilimab, to focused liver radiation (SBRT) can help people with chemorefractory, non‑MSI‑high colorectal cancer that has spread to the liver.

  Recruiting Early Phase 1 Massachusetts General Hospital · Boston, Massachusetts · NCT07128355

• Combination treatment for rectal adenocarcinoma using botensilimab and balstilimab

  This study is testing a new combination treatment with botensilimab and balstilimab to see if it can help people with locally advanced rectal cancer feel better with fewer side effects than regular chemotherapy.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06843434

• Neoadjuvant FOLFOX with botensilimab and balstilimab for localized rectal cancer

  This test tries whether giving FOLFOX chemotherapy together with the immune drugs botensilimab and balstilimab before surgery helps people with localized rectal cancer achieve a complete clinical response.

  Recruiting Phase 2 City of Hope Medical Center · Duarte, California · NCT06780787

• Treatment for advanced colorectal cancer using a new drug combination

  This study is testing a new combination of oral and intravenous medications to see if it can help people with advanced colorectal cancer that hasn't responded to previous treatments.

  Recruiting at 6 sites Phase 2 Stingray Therapeutics · Morristown, New Jersey and 5 other locations · NCT06589440

• Vaccine treatment for advanced colorectal and pancreatic cancer

  This study is testing a new vaccine combined with two other treatments to see if it can help people with advanced colorectal and pancreatic cancer who haven't responded to their first treatment.

  Recruiting Phase 1 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06411691

• Combining two immunotherapy drugs for MSI-H/dMMR advanced stomach and gastroesophageal junction cancer

  This trial will try two immunotherapy drugs (balstilimab and botensilimab) as first treatment for adults with MSI‑H/dMMR, HER2‑negative advanced or metastatic stomach or gastroesophageal‑junction cancer whose tumors have PD‑L1 CPS ≥5, and will compare that to standard chemotherapy with nivolumab.

  Recruiting at 7 sites Phase 3 Centre Leon Berard · Brest and 6 other locations · NCT06346197

• Combining botensilimab, balstilimab, a fasting mimicking diet, and vitamin C for KRAS-mutant metastatic colorectal cancer

  This study is testing if combining two new antibodies with a special diet and vitamin C can help people with KRAS-mutant metastatic colorectal cancer live longer and feel better.

  Recruiting at 3 sites Phase 1 University of Southern California · Fullerton, California and 2 other locations · NCT06336902

• Evaluating balstilimab for treating relapsed lymphoma

  This study is testing a new immunotherapy drug called balstilimab to see if it can help people with relapsed Hodgkin lymphoma or primary mediastinal B-cell lymphoma feel better.

  Recruiting Phase 2 Immune Oncology Research Institute · Yerevan · NCT05891821

• Combining Ivermectin with Balstilimab for Advanced Triple Negative Breast Cancer

  This study is testing whether combining ivermectin with balstilimab or pembrolizumab can help people with advanced triple negative breast cancer by shrinking tumors and improving their quality of life.

  Recruiting Phase 1/2 Cedars-Sinai Medical Center · Los Angeles, California · NCT05318469

Quick answers

How many clinical trials of Balstilimab are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (13 trials), France (1 trial), Armenia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 10, Phase 1: 2, Phase 1/2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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