Condition

Estrogen-receptor-positive Breast Cancer clinical trials and research

• 10Clinical trials
• 4Countries

Newest Estrogen-receptor-positive Breast Cancer clinical trials

All recruiting trials (10)

• Giredestrant in ER-positive, HER2-negative early breast cancer: who tolerates it and sticks with treatment

  This study tests how well people with ER-positive, HER2-negative early breast cancer can tolerate and stay on giredestrant, and how they feel during treatment.

  Recruiting Phase 3 Hoffmann-La Roche · Québec, Quebec · NCT07827573

• Adaptive biomarker-driven therapies for metastatic breast cancer

  This trial tests whether matching targeted drug combinations to tumor biomarkers helps people with ER+/HER2- or triple-negative metastatic breast cancer who are starting second-line treatment.

  Recruiting at 4 sites Phase 2 UNC Lineberger Comprehensive Cancer Center · New Haven, Connecticut and 5 other locations · NCT07340541

• Capecitabine with or without elacestrant for ER-positive advanced breast cancer

  This trial will try adding elacestrant to capecitabine to see if it helps people with ER-positive, HER2-negative advanced breast cancer that stopped responding to CDK4/6 inhibitors.

  Recruiting Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts · NCT07222215

• Re‑irradiating the breast after a second lumpectomy

  This trial will test whether targeted re‑irradiation (IMRT) after a second lumpectomy is safe for people with ER+ / HER2‑ breast cancer who previously received breast radiation.

  Recruiting at 2 sites Baptist Health South Florida · Boca Raton, Florida and 1 other locations · NCT06867484

• Treatment for advanced breast cancer using RYZ101

  This study is testing a new treatment called RYZ101 for people with advanced breast cancer that can't be removed by surgery to see if it helps manage their condition.

  Recruiting Phase 1/2 RayzeBio, Inc. · Phoenix, Arizona and 30 other locations · NCT06590857

• Adaptive capecitabine therapy for metastatic ER-positive, HER2-negative breast cancer

  This trial will try using capecitabine with dose changes based on tumor imaging and blood markers in adults with metastatic ER-positive, HER2-negative breast cancer.

  Recruiting Phase 2 Mayo Clinic · Scottsdale, Arizona · NCT06525766

• Sequential therapy for HER2-positive metastatic breast cancer

  This study is testing whether giving a specific order of HER2-targeted drugs can help people with HER2-positive metastatic breast cancer feel better and live longer.

  Recruiting Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts · NCT06439693

• Ketorolac and pregabalin to modify perioperative inflammation and nerve signaling in early ER+ breast cancer

  This trial will test whether giving short-term ketorolac, pregabalin, or both around surgery can blunt inflammatory and neural signals in adults having surgery for early estrogen-receptor–positive breast cancer.

  Recruiting Phase 2 Jules Bordet Institute · Brussels · NCT06150898

• Elacestrant with or without a CDK4/6 inhibitor for ER+/HER2- advanced or metastatic breast cancer

  This study will test whether adding a CDK4/6 inhibitor to elacestrant helps people with ER-positive, HER2-negative advanced or metastatic breast cancer who have an ESR1 mutation and prior CDK4/6 exposure.

  Recruiting at 2 sites Phase 2 Northwestern University · Chicago, Illinois and 2 other locations · NCT06062498

• Understanding how tumor shrinkage predicts cancer response in early breast cancer patients

  This study tests if measuring how much breast tumors shrink during chemotherapy can help predict how well the treatment will work for women with early-stage breast cancer.

  Recruiting at 2 sites Phase 2 Baylor Breast Care Center · Houston, Texas and 1 other locations · NCT05020860

Related topics

Quick answers

How many Estrogen-receptor-positive Breast Cancer clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (8 trials), Canada (2 trials), Belgium (1 trial), South Korea (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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