Condition
Metastatic Head and Neck Cancer clinical trials and research
As of November 12, 2026, Find a Trial lists 4 Metastatic Head and Neck Cancer clinical trials that are recruiting, at sites in 2 countries (most in United States (3), Italy (1)). By phase: Phase 2 (3), Phase 1 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 4Clinical trials
- 2Countries
Newest Metastatic Head and Neck Cancer clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Does the time of day for PD-1/PD-L1 therapy affect response in NSCLC and HNSCC | Phase 2 | Chapel Hill, North Carolina | Recruiting | Jun 5, 2026 |
| Pembrolizumab with ultrasound-induced microbubble cavitation for recurrent or metastatic head and neck cancer | Phase 1 | Philadelphia, Pennsylvania | Recruiting | Mar 30, 2026 |
| Combining chemotherapy with cetuximab and avelumab for advanced head and neck cancer | Phase 2 | Cagliari, CAGLIARI and 7 other locations | Recruiting | Mar 11, 2025 |
| Combination treatment for advanced head and neck cancer | Phase 2 | Boston, Massachusetts and 1 other locations | Recruiting | Feb 2, 2024 |
All recruiting trials (4)
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Does the time of day for PD-1/PD-L1 therapy affect response in NSCLC and HNSCC
In people with advanced NSCLC or resectable head and neck cancer, this study tests whether receiving PD-1/PD-L1 therapy in the morning versus the afternoon changes treatment outcomes.
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Pembrolizumab with ultrasound-induced microbubble cavitation for recurrent or metastatic head and neck cancer
We will try giving pembrolizumab together with ultrasound-triggered microbubbles to people with HPV-negative recurrent or metastatic head and neck cancer to help the drug reach tumors and improve response.
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Combining chemotherapy with cetuximab and avelumab for advanced head and neck cancer
This study is testing a new treatment plan that combines chemotherapy with two medications, cetuximab and avelumab, to see if it helps people with advanced head and neck cancer live longer without their disease getting worse.
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Combination treatment for advanced head and neck cancer
This study is testing a new combination treatment for people with advanced head and neck cancer to see if it can boost their immune response and help fight the disease.
Related topics
Quick answers
How many Metastatic Head and Neck Cancer clinical trials are recruiting right now?
4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 2 countries. The most sites are in United States (3 trials), Italy (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 3, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.