Condition

Resectable Head and Neck Squamous Cell Carcinoma clinical trials and research

• 7Clinical trials
• 2Countries

Newest Resectable Head and Neck Squamous Cell Carcinoma clinical trials

All recruiting trials (7)

• Does the time of day for PD-1/PD-L1 therapy affect response in NSCLC and HNSCC

  In people with advanced NSCLC or resectable head and neck cancer, this study tests whether receiving PD-1/PD-L1 therapy in the morning versus the afternoon changes treatment outcomes.

  Recruiting Phase 2 UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT07630168

• Pre-surgery sacituzumab govitecan plus tagitanlimab for operable head and neck squamous cell carcinoma

  This trial tests whether giving sacituzumab govitecan together with tagitanlimab before surgery helps people with resectable head and neck squamous cell carcinoma have better tumor responses and outcomes.

  Recruiting Phase 2 West China Hospital · Chengdu, Sichuan · NCT07492914

• Ivonescimab given before surgery for resectable stage II–IV head and neck cancer

  This trial tests whether giving ivonescimab before surgery helps people with resectable stage II–IV head and neck squamous cell carcinoma.

  Recruiting Phase 2 University of Michigan Rogel Cancer Center · Ann Arbor, Michigan · NCT07094685

• Decitabine plus standard surgery, radiation, and chemotherapy for HPV-negative operable head and neck cancer

  This trial will test whether adding decitabine to standard surgery and radiation/chemotherapy helps people with HPV-negative head and neck cancers that can be removed by surgery.

  Recruiting Phase 1 Mayo Clinic · Jacksonville, Florida · NCT06997094

• Decitabine plus standard surgery, radiation, and chemotherapy for HPV-negative operable head and neck cancer

  This trial will test whether adding decitabine to standard surgery and radiation/chemotherapy helps people with HPV-negative head and neck cancers that can be removed by surgery.

  Recruiting Phase 1 Mayo Clinic · Jacksonville, Florida · NCT06997094

• Combination of immunotherapy and chemotherapy for head and neck cancer treatment

  This study is testing if combining an immunotherapy drug with chemotherapy before and after surgery can help people with head and neck cancer do better.

  Recruiting Phase 2 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT05726370

• Combining immunotherapy and radiation for recurrent head and neck cancer

  This study is testing if combining a new immune treatment with radiation can help people with recurrent head and neck cancer feel better and live longer.

  Recruiting Phase 1 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT04754321

Related topics

Quick answers

How many Resectable Head and Neck Squamous Cell Carcinoma clinical trials are recruiting right now?

7, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (6 trials), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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