Condition
Metastatic Squamous Cell Carcinoma clinical trials and research
As of November 12, 2026, Find a Trial lists 3 Metastatic Squamous Cell Carcinoma clinical trials that are recruiting, in United States. By phase: Phase 2 (2), Phase 1 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 1Country
Newest Metastatic Squamous Cell Carcinoma clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Does the time of day for PD-1/PD-L1 therapy affect response in NSCLC and HNSCC | Phase 2 | Chapel Hill, North Carolina | Recruiting | Jun 5, 2026 |
| 5-Fluorouracil Response and Optimization (FROST) | Phase 2 | St Louis, Missouri | Recruiting | Feb 19, 2026 |
| Zanzalintinib with pembrolizumab and cetuximab for recurrent or metastatic head and neck squamous cell cancer | Phase 1 | Chicago, Illinois | Recruiting | Apr 4, 2025 |
All recruiting trials (3)
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Does the time of day for PD-1/PD-L1 therapy affect response in NSCLC and HNSCC
In people with advanced NSCLC or resectable head and neck cancer, this study tests whether receiving PD-1/PD-L1 therapy in the morning versus the afternoon changes treatment outcomes.
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5-Fluorouracil Response and Optimization (FROST)
This trial will test two different dosing schedules of 5‑fluorouracil as second-line-or-later treatment for people with recurrent or metastatic head and neck squamous cell carcinoma who have already had platinum and PD‑1 inhibitor therapy.
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Zanzalintinib with pembrolizumab and cetuximab for recurrent or metastatic head and neck squamous cell cancer
This trial tests whether adding the oral drug zanzalintinib to pembrolizumab and cetuximab is safe and finds the best dose for adults with recurrent or metastatic head and neck squamous cell cancer.
Related topics
Quick answers
How many Metastatic Squamous Cell Carcinoma clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.