Condition

Metabolic Health clinical trials and research

• 14Clinical trials
• 71NIH research projects
• 6Countries

Newest Metabolic Health clinical trials

All recruiting trials (14)

• Bringing preventive cardiovascular care to Indigenous and remote communities

  This project tests a mobile health unit to screen and provide culturally safe cardiovascular and metabolic care for Indigenous and remote communities in Canada.

  Recruiting Laval University · Québec, Quebec · NCT07869069

• Do Quercefit® or Ubiqsome™ help with aging and metabolic health in adults 50–75?

  This study tests whether Quercefit® or Ubiqsome™ can improve aging markers, blood sugar, and heart health in sedentary adults aged 50–75 compared with a placebo.

  Recruiting Applied Science & Performance Institute · Tampa, Florida · NCT07760506

• Diet, Fat Quality, and How Your Body Responds to Exercise

  This observation study tests whether your usual fat quality in diet and metabolic health relate to how you feel during and after exercise, plus your cognitive function and school-related engagement.

  Recruiting University of Wisconsin, River Falls · River Falls, Wisconsin · NCT07728240

• Agentic AI personalized dietary management

  This study tests an AI-powered, personalized diet plan to see if it helps adults improve eating habits and metabolic health over 12 weeks.

  Recruiting Seoul National University Hospital · Seoul, Seoul · NCT07638241

• Dance Exercise for Metabolic and Mental Health in Women

  A 6-month program of supervised dance workouts will be tested to see if it improves metabolic health, mental health, and physical performance in premenopausal and postmenopausal inactive women in Greece.

  Recruiting University of Thessaly · Trikala, Karies · NCT07615829

• Dairy versus plant-based yogurt effects on weight, muscle, bones, and gut bacteria

  This study will test whether eating dairy yogurt instead of a plant-based yogurt (or no yogurt) helps postmenopausal women with overweight or obesity maintain muscle and bone health, control weight, and change gut bacteria.

  Recruiting Laval University · Québec, Quebec · NCT07578103

• How different cycling training loads change gut bacteria, butyrate, fitness, and overreaching in healthy men

  This project will test whether supervised moderate or high indoor cycling changes gut bacteria and butyrate levels and whether those changes relate to fitness, muscle health, and signs of overreaching in healthy recreational men aged 18–45.

  Recruiting KU Leuven · Leuven, Vlaams Brabant · NCT07481578

• Women's Hormonal and Metabolic Wellbeing

  This 12-week test will see if taking Daily Nouri's Hormone Balance probiotic every day helps women with irregular menstrual cycles and hormone-related symptoms improve metabolic markers, inflammation, and daily symptoms.

  Recruiting Daily Nouri · San Francisco, California · NCT07268404

• Understanding what drives insulin resistance in healthy adults

  This study tests how short-term changes in activity or diet affect insulin sensitivity in healthy adults to see if different people have different underlying causes.

  Recruiting University of Copenhagen · Copenhagen · NCT07255807

• A large-scale digital health study using Apple devices

  This study is trying to see how data from Apple devices can help us understand and manage different health issues like mental health, sleep, and exercise for a wide range of people.

  Recruiting at 2 sites Apple Inc. · Washington D.C., District of Columbia and 1 other locations · NCT06958523

• Substituting high- with low-ultra-processed soy protein foods within a guideline-based diet for cardiometabolic health

  This study tests whether a 12-week digital diet program with extra fruits and vegetables, combined with either low- or high-ultra-processed soy protein foods, can lower systolic blood pressure in adults with hypertension and obesity, about half of whom have type 2 diabetes.

  Recruiting University of Toronto · Toronto, Ontario · NCT06907862

• Dairy intake and metabolic health in teens and older adults

  This project will test whether eating three servings of dairy each day helps overweight or obese teens (15–18) and older adults (60–80) improve weight, body composition, and metabolic health over six months.

  Recruiting University of Toronto · Toronto, Ontario and 1 other locations · NCT06879652

• Nutritional programs to improve metabolic health

  This study is testing if a special diet and supplements can help people with obesity improve their metabolic health over four months.

  Recruiting Viome · Bothell, Washington · NCT05564273

• Examining the impact of green spaces on heart health in Louisville

  This study is testing if having more green spaces in Louisville can help improve heart health and reduce disease risk for the people living there.

  Recruiting University of Louisville · Louisville, Kentucky · NCT03670524

NIH-funded research (newest 40 of 71)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Metabolic Health and Lifestyle in Down Syndrome and Risk of Related Health Conditions

  A nationwide study aims to understand how metabolic health and daily habits affect health conditions like Alzheimer’s-related changes in people with Down syndrome.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11541246

• Brown-fat lipids and their mimics for better metabolism

  Researchers are studying small fat-related molecules produced by brown fat to understand how they help with metabolism and may lead to new ways to treat type 2 diabetes.

  NIH research Joslin Diabetes Center · Boston, United States · NIH-11450895

• GROW Together: How a mother’s blood sugar affects a baby’s growth and future health in American Samoa

  A study following pregnant Pacific Islander women in American Samoa to understand how glucose levels during pregnancy influence their babies’ early growth and later risk of diabetes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11448466

• Aina-Based Engagement and Social Epigenomic Pathways to Metabolic Health for Native Hawaiian Youth

  A Native Hawaiian youth program combines Indigenous knowledge with modern science to understand and improve blood sugar health and inflammation through community-led farming and gut microbiome changes.

  NIH research University of Hawaii at Manoa · Honolulu, United States · NIH-11443962

• Glyphosate exposure and young adults' metabolic health

  A study will look at how glyphosate exposure relates to metabolism and liver health in young adults, using urine measurements and health data.

  NIH research University of California Berkeley · Berkeley, United States · NIH-11432034

• Musculoskeletal and Metabolic Health in midlife women during menopause

  A long-term study following women through menopause to understand how bone, muscle, and metabolic health change and affect aging.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11421746

• PrEP and heart/kidney/metabolic health: what long-term PrEP could mean for people at risk for HIV

  This study looks at how long-term HIV PrEP with common medicines might affect heart, kidney, and metabolic health in people who don’t have HIV.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11415212

• Understanding how the gut microbiome influences energy use and metabolic health

  A study from Harvard will explore how our gut microbes affect how we get and use energy from food and how lifestyle factors like diet and exercise change this in ways that could impact metabolic health.

  NIH research Harvard University · Cambridge, United States · NIH-11406341

• Ano4's role in body weight and glucose balance

  A scientists at the University of South Florida are studying how a brain ion channel called Ano4 in the area postrema influences food intake, body weight, and blood sugar in mice, to better understand obesity in people.

  NIH research University of South Florida · Tampa, United States · NIH-11402435

• Gut microbiome and intestinal development after fetal growth restriction

  A researcher is studying how gut microbes and intestinal growth interact after fetal growth restriction to influence obesity and type 2 diabetes risk.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11400303

• Sleep and circadian rhythms and their impact on metabolic health

  This research explores how not getting enough sleep and misaligned body clocks affect obesity, diabetes, and metabolism in people.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11395400

• Molecular pathways of energy balance beyond UCP1 in fat tissue

  A study to understand how fat tissue can generate energy and heat without the classic UCP1 protein, aiming to find new ways to support metabolic health.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11387771

• Food insecurity and heart and metabolic health in young adults

  This study looks at how not having enough food affects heart and metabolic health in college students and young adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11382864

• Placental gene therapy to help babies grow healthy and reduce future diabetes risk

  A child-focused approach aims to safely boost a key growth factor in the placenta during pregnancy to lower the chance of metabolic problems like diabetes in the child later in life.

  NIH research University of Florida · Gainesville, United States · NIH-11382265

• Exercise, exosomes, and metabolic health in type 2 diabetes

  A study to understand how exercise changes tiny particles released by muscles to improve insulin sensitivity in Native Hawaiian and Pacific Islander adults with type 2 diabetes.

  NIH research University of Hawaii at Manoa · Honolulu, United States · NIH-11377127

• Metabolic health during puberty in youth at risk for type 2 diabetes

  This project follows children through puberty to understand how metabolism and glucose control change, with the goal of preventing youth-onset type 2 diabetes.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11374938

• How fat tissue fuels insulin resistance in people living with HIV

  This project looks at why people living with HIV have higher insulin resistance and diabetes risk, focusing on fat tissue, fibrosis, and the biology of fat cells.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11369237

• Exercise and fat tissue: how workouts change fat tissue and metabolic health during weight loss and regain

  A study to understand how adding exercise to a weight loss plan affects fat tissue and overall metabolic health in people with obesity.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11345409

• FEASible: Sensing daily life to understand metabolic health in women

  Aims to use wearable devices, phones, and environmental sensors to understand how daily activity, sleep, and surroundings relate to metabolic health in women of childbearing age.

  NIH research University of Texas at Austin · Austin, United States · NIH-11332918

• Role of human milk components on metabolic health in breastfeeding children of mothers with HIV

  A study to understand how breast milk from mothers with HIV and ART exposure may affect the metabolic health and growth of their breastfeeding children.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11328374

• Gut bacteria fats, fiber, and metabolic health

  This project looks for fat-like molecules made by gut bacteria and how dietary fiber and a person's metabolic health change them in adults with type 2 diabetes.

  NIH research University of California at Davis · Davis, United States · NIH-11326806

• Stopping fat-driven cell damage to protect metabolic health

  Testing whether removing certain tiny RNAs inside cells can prevent fat-related liver and metabolic damage in adults with type 2 diabetes.

  NIH research Joslin Diabetes Center · Boston, United States · NIH-11324243

• Pregnancy chemical exposures and women's heart and metabolic health later in life

  This research looks at whether chemical exposures before and during pregnancy affect women's heart and metabolic health later in life.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11319786

• Investigating the link between pancreatic fat and childhood metabolic health

  This study is looking at how the amount of fat in the pancreas and its size can affect the health of kids and teens, especially those who are overweight, to see if it might lead to type 2 diabetes, and it involves MRI scans to get a closer look at these factors.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11309744

• How a mother's insulin and placenta signaling shape a child's future metabolism

  This work looks at how high insulin in pregnant people changes the placenta and may raise their children's risk for Type 2 diabetes later in life.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11303252

• Influence of the malate-aspartate shuttle on muscle energy and performance

  This grant explores how a key energy shuttle in muscle cells affects how well our muscles perform and adapt to exercise.

  NIH research University of Louisville · Louisville, United States · NIH-11268663

• Nutrition and Metabolic Health Center: Advancing Heart, Liver, and Metabolic Health

  A center at the University of Louisville will build new nutrition and metabolism research to prevent and treat common metabolic and cardiovascular diseases.

  NIH research University of Louisville · Louisville, United States · NIH-11268657

• High-fructose diets, gut bacteria, and blood sugar

  This project compares short periods of high-fructose versus high-glucose diets in adults to see how the gut microbiome and blood sugar-related measures change.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11243472

• ANO4's effect on appetite, weight, and blood sugar

  This work looks at whether changes in the ANO4 gene and its brain channel influence appetite, body weight, and blood sugar for people with obesity.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11195119

• Understanding Fat Tissue Changes and Metabolic Health in People with HIV

  This work explores how changes in fat tissue might lead to insulin resistance and type 2 diabetes in people living with HIV.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11190987

• Understanding health challenges faced by low-income Black and Hispanic women with and without HIV

  This study is looking at how being low-income and facing challenges like type 2 diabetes, depression, and HIV affects the health of Black and Hispanic women, with the goal of finding better ways to support their well-being.

  NIH research New York University · New York, United States · NIH-11174482

• How acid balance affects muscle energy and endurance in people with chronic kidney disease

  The project seeks to help people with chronic kidney disease by treating metabolic acidosis to improve muscle energy use and physical endurance.

  NIH research University of California at Davis · Davis, United States · NIH-11170665

• How short sleep and a shifted body clock affect weight and blood sugar

  This project tests whether chronic short sleep and disruptions to your internal clock change eating habits and blood sugar in adults.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11158785

• Understanding Fat Tissue Changes for Better Metabolic Health

  This research explores how fat tissue can be changed to improve overall metabolic health, especially for people with conditions like type 2 diabetes.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11132818

• How fat cells make heat without the usual UCP1 protein

  This research looks at a different molecular pathway in fat that helps produce heat and could be relevant for people with obesity or metabolic problems.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11128188

• How not having reliable food affects young adults' heart and metabolic health

  This research looks at how not having enough reliable food affects heart and metabolic health in college students and young adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11125900

• How certain environmental chemicals affect fat development and metabolic health in zebrafish

  This study is looking at how certain chemicals found in everyday products might affect our body's ability to manage fat and stay healthy, using zebrafish to see what happens when they're exposed to these substances during their growth.

  NIH research Wayne State University · Detroit, United States · NIH-11125099

• Understanding Metabolic Health in Young People During Puberty

  This project follows children and their mothers over time to learn how metabolic health changes during puberty and why some young people develop type 2 diabetes.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11121917

• Understanding Exercise's Benefits for Type 2 Diabetes

  This project aims to understand how exercise helps improve health for people with Type 2 Diabetes, especially Native Hawaiians and other Pacific Islanders, by looking at tiny cell messengers called exosomes.

  NIH research University of Hawaii at Manoa · Honolulu, United States · NIH-11115770

• Exploring how gut bacteria and dietary fibers affect health through microbial fats

  This study is looking at how what we eat affects the tiny microbes in our gut and how they, in turn, influence our health, focusing on special compounds called xenolipids, which could help us understand better ways to improve our well-being through diet.

  NIH research University of California at Davis · Davis, United States · NIH-11113985

Related topics

Quick answers

How many Metabolic Health clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (6 trials), Canada (4 trials), South Korea (1 trial), Belgium (1 trial), Greece (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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