Sleep and circadian rhythms and their impact on metabolic health
Official title: Uncovering sleep and circadian mechanisms contributing to adverse metabolic health
Funded at Oregon Health & Science University · NIH-11395400 · Data updated 2026-11-12
This research explores how not getting enough sleep and misaligned body clocks affect obesity, diabetes, and metabolism in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $569,543 |
| NIH project number | 5R01HL169317-04 |
| Project ID | NIH-11395400 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with varied sleep patterns who are of typical health range and willing to participate in a sleep/ circadian study.
✕Less likely to help
Individuals with conditions preventing participation in sleep restriction or those unwilling to undergo randomized sleep manipulation may not benefit.
What this research studies
The researchers will study how chronic sleep restriction and circadian disruption, separately and together, change energy intake, food choices, and glucose tolerance. They plan a 14-day randomized protocol to tease apart the effects of sleep loss and clock timing on metabolic health. The goal is to identify specific patterns in eating and metabolism that emerge when sleep is restricted and circadian timing is altered. By understanding these mechanisms, the study aims to point toward targeted strategies to improve metabolic health in people who experience poor sleep.
Why it matters
Potential benefit: If successful, the work could lead to better sleep- and circadian-based interventions to prevent or manage obesity and diabetes.
How similar studies have gone: Previous work has shown links between sleep loss and metabolism, but this project seeks to disentangle independent vs. combined effects of sleep restriction and circadian timing.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Mchill, Andrew William — Oregon Health & Science University
- Study coordinator: Mchill, Andrew William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.