Influence of the malate-aspartate shuttle on muscle energy and performance
Official title: Influence of the malate-aspartate shuttle in striated muscle metabolic health and performance
Funded at University of Louisville · NIH-11268663 · Data updated 2026-11-12
This grant explores how a key energy shuttle in muscle cells affects how well our muscles perform and adapt to exercise.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | May 15, 2026 |
| Project end | January 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $331,518 |
| NIH project number | 1P20GM161999-01 |
| Project ID | NIH-11268663 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with conditions affecting muscle energy metabolism or those interested in improving exercise performance may be eligible for related studies or future trials.
✕Less likely to help
People without muscle metabolic concerns or those not engaging in exercise-based interventions may derive no direct benefit.
What this research studies
Researchers at the University of Louisville will study how the malate-aspartate shuttle influences energy production, redox balance, and adaptation in skeletal and cardiac muscle during and after exercise. The project will examine how cytosolic and mitochondrial communication within muscle cells supports energy use from glucose and fats, as well as how this process changes with training. By understanding these pathways, the study aims to identify factors that could improve exercise capacity and metabolic health for people living with related conditions.
Why it matters
Potential benefit: Understanding MAS function could lead to approaches that improve exercise tolerance and metabolic health.
How similar studies have gone: Previous research shows that muscle energy pathways and redox balance impact exercise adaptation, but the specific MAS role in humans requires further clarification.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Gibb, Andrew a — University of Louisville
- Study coordinator: Gibb, Andrew a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.