PrEP and heart/kidney/metabolic health: what long-term PrEP could mean for people at risk for HIV
Official title: Effects of HIV Pre-Exposure Prophylaxis (PrEP) on Cardiovascular-Kidney-Metabolic Health and Risk for Cardiovascular Disease
Funded at Kaiser Foundation Research Institute · NIH-11415212 · Data updated 2026-11-12
This study looks at how long-term HIV PrEP with common medicines might affect heart, kidney, and metabolic health in people who don’t have HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kaiser Foundation Research Institute NIH-funded |
| Lab location | 1 site (Oakland, UNITED STATES) |
| Project start | September 5, 2025 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $730,229 |
| NIH project number | 5R01HL178400-02 |
| Project ID | NIH-11415212 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults at risk for HIV who are using or planning to start tenofovir-based PrEP.
✕Less likely to help
Individuals who are not using PrEP or do not have risk factors for HIV may not directly benefit from this research.
What this research studies
Researchers will follow a diverse group of individuals using tenofovir-based PrEP to see how it impacts metabolic factors, kidney function, and cardiovascular risk over time. The project aims to gather long-term data since many PrEP users may be older and have other health issues. By linking metabolic and renal outcomes, the study hopes to inform clinical management and prevention strategies for people at risk of HIV. The findings could help doctors tailor PrEP choices and monitoring to protect heart and kidney health.
Why it matters
Potential benefit: If successful, the study could guide safer PrEP use and monitoring to reduce cardiovascular and kidney risks for people at risk of HIV.
How similar studies have gone: Prior PrEP studies provide some data, but long-term, diverse population data on CKM health is limited and this study seeks to fill that gap.
Where this research is happening
-
Kaiser Foundation Research Institute
Oakland, United States Active
Researchers
- Principal investigator: Hechter, Rulin C — Kaiser Foundation Research Institute
- Study coordinator: Hechter, Rulin C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.