How certain environmental chemicals affect fat development and metabolic health in zebrafish
Official title: Environmental ethoxylated surfactants and metabolic health dysregulation in zebrafish
Funded at Wayne State University · NIH-11125099 · Data updated 2026-11-12
This study is looking at how certain chemicals found in everyday products might affect our body's ability to manage fat and stay healthy, using zebrafish to see what happens when they're exposed to these substances during their growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | June 3, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $756,318 |
| NIH project number | 1R01ES036178-01A1 |
| Project ID | NIH-11125099 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals, particularly children and adults, who are affected by obesity or metabolic disorders.
✕Less likely to help
Patients who are not affected by obesity or metabolic disorders may not receive direct benefits from this research.
What this research studies
This research investigates the impact of environmental chemicals, specifically polyethoxylated surfactants, on metabolic health and fat development using zebrafish as a model organism. The study aims to understand how these chemicals, commonly found in household products, may contribute to obesity and metabolic disorders by affecting energy balance and fat accumulation. By exposing zebrafish to these chemicals during their development, researchers will assess changes in adipose tissue and overall metabolic function. The findings could provide insights into the risks posed by these contaminants to human health.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of how environmental chemicals contribute to obesity and metabolic disorders, potentially informing public health policies and consumer safety regulations.
How similar studies have gone: Previous research has indicated that environmental contaminants can disrupt metabolic health, suggesting that this approach may yield valuable insights into the effects of polyethoxylated surfactants.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Kassotis, Christopher Dennis — Wayne State University
- Study coordinator: Kassotis, Christopher Dennis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.