Condition
Locked-in Syndrome clinical trials and research
As of November 12, 2026, Find a Trial lists 6 Locked-in Syndrome clinical trials that are recruiting, at sites in 3 countries (most in United States (4), China (1), Netherlands (1)). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 6Clinical trials
- 3Countries
Newest Locked-in Syndrome clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Decoding Mandarin speech features from brain-surface signals | — | Hangzhou, Zhejiang | Recruiting | Mar 10, 2026 |
| Communication through a brain implant for people with locked-in syndrome | — | Utrecht | Recruiting | Jan 17, 2024 |
| Using a brain-computer interface to help people with speech difficulties communicate | — | Sacramento, California | Recruiting | Oct 23, 2023 |
| Using a neural interface to help people with tetraplegia control devices with their thoughts | — | Stanford, California and 1 other locations | Recruiting | Feb 13, 2023 |
| Investigation of a brain-computer interface system for communication in patients with severe disabilities | — | Baltimore, Maryland | Recruiting | Jun 25, 2018 |
| Feasibility of a brain-computer interface for people with tetraplegia | — | Sacramento, California and 5 other locations | Recruiting | Jun 3, 2009 |
All recruiting trials (6)
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Decoding Mandarin speech features from brain-surface signals
This project will try to decode imagined Mandarin speech, including lexical tones, from high-density brain-surface (ECoG) signals in adult patients who are having clinically indicated cortical electrode placement.
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Communication through a brain implant for people with locked-in syndrome
This study is testing a brain implant that helps people with locked-in syndrome communicate by translating their brain activity into messages.
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Using a brain-computer interface to help people with speech difficulties communicate
This study is testing a brain-computer interface to help people who can't speak due to conditions like ALS communicate by turning their thoughts into speech.
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Using a neural interface to help people with tetraplegia control devices with their thoughts
This study is testing a new brain interface that helps people with tetraplegia, especially those with ALS, control devices like computers just by thinking about it.
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Investigation of a brain-computer interface system for communication in patients with severe disabilities
This study is testing a new brain-computer interface that helps people with severe disabilities, like tetraplegia and ALS, communicate better by using signals from their brain.
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Feasibility of a brain-computer interface for people with tetraplegia
This study is testing a new brain-computer interface that helps people with tetraplegia control a computer and other devices just by thinking, to see if it’s safe and effective.
Related topics
Quick answers
How many Locked-in Syndrome clinical trials are recruiting right now?
6, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 3 countries. The most sites are in United States (4 trials), China (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.