Condition

Locally Advanced Breast Cancer clinical trials and research

• 14Clinical trials
• 4NIH research projects
• 1New in 30 days
• 28Countries

Newest Locally Advanced Breast Cancer clinical trials

All recruiting trials (14)

• PRT13722 in advanced HR+/HER2- breast cancer

  This early study tests PRT13722, by itself and with standard therapies, to see if it is safe and has any signs of activity in adults with HR+/HER2- breast cancer who have progressed on prior treatments.

  Recruiting Phase 1 Prelude Therapeutics Incorporated · Maumee, Ohio · NCT07905001

• Inavolisib-based treatment for endocrine-resistant PIK3CA-mutated HR+/HER2- advanced breast cancer

  This trial tests an inavolisib-based regimen in people in China who have endocrine-resistant, PIK3CA-mutated, hormone receptor–positive, HER2‑negative locally advanced or metastatic breast cancer after finishing adjuvant endocrine therapy.

  Recruiting at 32 sites Hoffmann-La Roche · Xiamen, Fujian and 31 other locations · NCT07347600

• Palazestrant plus ribociclib as first-line treatment for ER+/HER2- advanced breast cancer

  This trial will test whether using palazestrant instead of letrozole, both given with ribociclib, helps adults with ER+/HER2- advanced breast cancer who have not had prior systemic treatment for their advanced disease.

  Recruiting at 198 sites Phase 3 Olema Pharmaceuticals, Inc. · Hot Springs, Arkansas and 199 other locations · NCT07085767

• HRS-8080 versus doctor‑chosen treatments for locally advanced or metastatic breast cancer

  This trial will test whether the oral drug HRS-8080 works better than treatments chosen by doctors for women with locally advanced or metastatic breast cancer whose disease progressed after prior endocrine therapy.

  Recruiting at 2 sites Phase 3 Shandong Suncadia Medicine Co., Ltd. · Guangzhou, Guangdong and 1 other locations · NCT07024173

• Finding the best dose of BNT323 and BNT327 for advanced breast cancer

  This study is testing the best dose of a new combination treatment for advanced breast cancer to see how well it works and if it's safe for patients.

  Recruiting at 84 sites Phase 1/2 BioNTech SE · Beverly Hills, California and 83 other locations · NCT06827236

• Memantine plus structured exercise to protect thinking and memory during breast cancer chemotherapy

  This will test whether memantine combined with a supervised exercise program, memantine alone, or a placebo can prevent or reduce thinking and memory problems in people receiving chemotherapy for stage I–III breast cancer.

  Recruiting Phase 2 UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06727773

• Evaluating lymph node dissection for breast cancer treatment

  This study is testing if a specific type of surgery for breast cancer can help patients live longer and have fewer complications compared to regular radiation treatment.

  Recruiting Henan Cancer Hospital · Zhengzhou, Henan · NCT06605521

• Combining pembrolizumab with cryoablation for metastatic breast cancer

  This study is testing if combining a drug called pembrolizumab with a freezing treatment can help people with advanced triple negative breast cancer feel better compared to just using the drug alone.

  Recruiting at 7 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06246968

• Using advanced mammography techniques to assess breast cancer treatment response

  This study is testing two new mammography techniques to see if they can better predict how well chemotherapy is working for people with locally advanced breast cancer.

  Recruiting Early Phase 1 Stony Brook University · Stony Brook, New York · NCT06220214

• Testing FWD1802 for ER+/HER2- breast cancer

  This study is testing a new treatment called FWD1802, alone and with another drug, to see if it can help people with advanced ER+/HER2- breast cancer feel better and improve their outcomes.

  Recruiting at 20 sites Phase 1/2 Forward Pharmaceuticals Co., Ltd. · Hefei, Anhui and 21 other locations · NCT06064812

• Exercise program for breast cancer patients

  This study tests whether a 24-week exercise program can improve fitness, strength, and quality of life for breast cancer patients who have finished their treatment.

  Recruiting at 3 sites National Cancer Centre, Singapore · Singapore and 2 other locations · NCT05957068

• Precision neoadjuvant therapy for operable breast cancer

  This study is testing if a personalized treatment approach using new drugs for operable breast cancer can work better than standard chemotherapy alone.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT05582499

• Using pyrotinib to prevent recurrence in HER-2 positive breast cancer

  This study is testing if the drug pyrotinib can help prevent breast cancer from coming back in women who have already been treated for HER2-positive breast cancer.

  Recruiting Phase 3 RenJi Hospital · Shanghai, Shanghai Municipality · NCT04254263

• Personalized treatment for breast cancer using new drug agents

  This study is testing new drug combinations with standard chemotherapy to see which treatments work best for different types of breast cancer based on the specific characteristics of each patient's tumor.

  Recruiting at 32 sites Phase 2 QuantumLeap Healthcare Collaborative · Birmingham, Alabama and 41 other locations · NCT01042379

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Using a blood test that looks for tumor DNA to monitor early and locally advanced breast cancer

  This project uses a sensitive blood test that looks for tiny bits of tumor DNA to track treatment response in people with early or locally advanced breast cancer.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11306078

• Monitoring breast cancer treatment using blood tests for tumor DNA

  This study is looking at how to better treat people with early and locally advanced breast cancer by checking for tiny bits of cancer DNA in their blood, which could help doctors spot any remaining cancer sooner and tailor treatments to each patient, reducing the chance of unnecessary therapies.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11136406

• Investigating factors that affect blood tests for early breast cancer detection

  This study is looking at how different ways of collecting and processing blood samples can help improve blood tests that check for early signs of breast cancer, and it's for patients with early or locally advanced breast cancer.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-10691211

• Examining lymph node biopsy techniques after chemotherapy in advanced breast cancer patients

  This study is looking at whether a less invasive procedure called sentinel lymph node biopsy can help women with locally advanced breast cancer who have received chemotherapy, making it easier to check for cancer spread in the armpit without needing more complicated surgeries.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10656553

Related topics

Quick answers

How many Locally Advanced Breast Cancer clinical trials are recruiting right now?

14, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 28 countries. The most sites are in United States (7 trials), China (7 trials), Australia (2 trials), Canada (2 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 2: 3, Phase 1/2: 2, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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