Condition

Breast Cancer Stage I clinical trials and research

• 16Clinical trials
• 6Countries

Newest Breast Cancer Stage I clinical trials

All recruiting trials (16)

• Capecitabine for MRD-positive, resected ER+/HER2-negative breast cancer

  This Phase 2 trial tests whether taking capecitabine can help people with resected, ER-positive/HER2-negative breast cancer who still have molecular residual disease after standard therapy.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT07631052

• Adding TheraBionic P1 radiofrequency therapy to treatment for early-stage HR+ HER2- breast cancer

  This study will try giving TheraBionic P1 amplitude-modulated radiofrequency therapy before surgery to see if it improves tumor response in women with early-stage, hormone receptor–positive, HER2-negative breast cancer.

  Recruiting at 8 sites Barbara Ann Karmanos Cancer Institute · Clarkston, Michigan and 7 other locations · NCT07218432

• Combining FWD1802 with CDK4/6 inhibitors or everolimus for ER+/HER2- advanced breast cancer

  This trial tests whether adding FWD1802 to CDK4/6 inhibitors or everolimus helps people with ER-positive/HER2-negative unresectable locally advanced or metastatic breast cancer who have progressed on or cannot use standard therapy.

  Recruiting Phase 1/2 Forward Pharmaceuticals Co., Ltd. · Shanghai · NCT07002177

• Using PTFE mesh for breast reconstruction in cancer patients

  This study tests if using a special mesh called PTFE can help women with early-stage breast cancer have better and safer breast reconstruction compared to a traditional method.

  Recruiting Branch Office of "Hadassah Medical Ltd" · Moscow, Skolkovo Innovation Center · NCT06931548

• Predicting how hormone therapy before surgery affects breast cancer

  This study is testing how hormone therapy before surgery can help people with early-stage breast cancer and what it means for their tumors.

  Recruiting Phase 2 George Washington University · Washington D.C., District of Columbia · NCT06806930

• Meal timing during cancer treatment for Alaska Native and American Indian patients

  This test will see if an 8-hour time-restricted eating schedule during neoadjuvant or adjuvant therapy helps Alaska Native and American Indian adults with rectal or certain breast cancers.

  Recruiting Fred Hutchinson Cancer Center · Anchorage, Alaska · NCT06802172

• Decision-making tool to help women with early breast cancer choose treatment

  This project will test a patient decision aid to help women with early-stage breast cancer make treatment choices.

  Recruiting European Institute of Oncology · Milan, Italy · NCT06762496

• Memantine plus structured exercise to protect thinking and memory during breast cancer chemotherapy

  This will test whether memantine combined with a supervised exercise program, memantine alone, or a placebo can prevent or reduce thinking and memory problems in people receiving chemotherapy for stage I–III breast cancer.

  Recruiting Phase 2 UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT06727773

• Optimizing treatment for low stage triple-negative breast cancer patients

  This study is testing if patients with early-stage triple-negative breast cancer can skip chemotherapy after surgery and radiation if they have certain positive signs, to see how it affects their safety and quality of life.

  Recruiting at 18 sites The Netherlands Cancer Institute · Sittard-Geleen, Limburg and 27 other locations · NCT06476119

• Improving surgical decisions for young women with breast cancer

  This study is testing a new online tool to help young women with breast cancer make better surgical decisions and communicate more effectively with their doctors.

  Recruiting at 4 sites Weill Medical College of Cornell University · New Haven, Connecticut and 3 other locations · NCT06275126

• Using tart cherry juice to prevent nerve damage from chemotherapy in breast cancer patients

  This study is testing if drinking tart cherry juice can help prevent nerve damage in breast cancer patients receiving chemotherapy.

  Recruiting Phase 2 University of California, Davis · Sacramento, California · NCT06268665

• Evaluating skin reactions in breast cancer patients receiving proton therapy

  This study is testing a new technique to see if it can help reduce skin reactions in breast cancer patients getting proton therapy.

  Recruiting Covenant Health Cancer Center · Knoxville, Tennessee · NCT06006806

• Virtual rehabilitation program for cancer survivors

  This study is testing an 8-week online rehab program for cancer survivors to see if it helps them feel better physically and socially after treatment.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05898789

• Combining Pyrotinib and Capecitabine for Early HER2 Positive Breast Cancer

  This study is testing if combining two medications, pyrotinib and capecitabine, can help women with early-stage HER2-positive breast cancer feel better and improve their treatment outcomes.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT05861271

• Combining chemotherapy and radiation for high-risk breast cancer patients

  This study tests whether combining chemotherapy and radiation can help high-risk breast cancer patients who still have cancer after initial treatment, while also looking at how this treatment affects their immune system.

  Recruiting Phase 2/3 University of Virginia · Charlottesville, Virginia · NCT05288777

• Using Harmonic Motion Imaging for Non-Invasive Breast Tumor Treatment

  This study is testing if a new imaging method can help guide a non-invasive ultrasound treatment for people with benign breast tumors and early-stage breast cancer to see if it leads to better recovery and results.

  Recruiting Phase 1 Columbia University · New York, New York · NCT05219695

Related topics

Quick answers

How many Breast Cancer Stage I clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (9 trials), China (2 trials), Canada (2 trials), Italy (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1/2: 1, Phase 1: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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